Koutcherov Y, Ashwell K W, Paxinos G
School of Psychology, The University of New South Wales, Sydney, Australia.
Neuroreport. 2000 Sep 28;11(14):3127-31. doi: 10.1097/00001756-200009280-00018.
The neurokinin B receptor (NK3) is an element of the hypothalamic neuronal circuitry regulating blood pressure in rats. The present study used immunohistochemistry to reveal the distribution of NK3 in the human hypothalamus. The strongest NK3-like immunoreactivity in the human hypothalamus was found in neurons of the paraventricular nucleus, specifically in the parvicellular and posterior paraventricular subnuclei. Another prominent population of NK3-positive cells in the human hypothalamus was found in the perifornical nucleus. The present study also showed two previously unreported populations of NK3-positive neurons in the rat periventricular nucleus and medial magnocellular paraventricular subnucleus. It is concluded that there is a large degree of similarity in the distribution of NK3 in the human and rat hypothalamus.
神经激肽B受体（NK3）是大鼠下丘脑调节血压的神经回路的一个组成部分。本研究采用免疫组织化学方法揭示NK3在人类下丘脑中的分布。人类下丘脑中最强的NK3样免疫反应性见于室旁核的神经元，特别是小细胞和室旁后亚核。在穹窿周核中发现了人类下丘脑中另一群突出的NK3阳性细胞。本研究还显示，在大鼠室周核和室旁大细胞内侧亚核中有两群先前未报道的NK3阳性神经元。得出的结论是，NK3在人类和大鼠下丘脑中的分布有很大程度的相似性。
