Dechent P, Frahm J
Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut for biophysikalische Chemie, Göttingen, Germany.
Neuroreport. 2000 Sep 28;11(14):3247-9. doi: 10.1097/00001756-200009280-00039.
Functional magnetic resonance imaging at 2.0T was employed to identify columnar structures in human visual cortex. Sagittal sections (4 mm thickness) covering the calcarine cortex were acquired with use of a multiecho low flip angle gradient-echo sequence at 4.0 s temporal resolution and 0.25 x 0.25 mm2 spatial resolution. Extending earlier attempts based on a differential paradigm contrasting left vs right eye stimulation, this work presents the first direct mapping of human ocular dominance columns by measuring separate activation maps with left and right eye stimulation. The resulting individual maps reveal patterns of ocular dominance as spots or bands of altered activity in calcarine cortex. Their superposition shows only little spatial overlap of eye-specific encoding which strongly supports the genuineness of these functional units.
采用2.0T功能磁共振成像来识别人类视觉皮层中的柱状结构。使用多回波低翻转角梯度回波序列，以4.0秒的时间分辨率和0.25×0.25平方毫米的空间分辨率采集覆盖距状皮质的矢状切片（厚度为4毫米）。基于对比左眼与右眼刺激的差异范式扩展早期尝试，这项工作通过测量左眼和右眼刺激下的单独激活图，首次对人类眼优势柱进行了直接映射。所得的个体图显示，眼优势模式表现为距状皮质中活动改变的斑点或条带。它们的叠加显示出眼特异性编码的空间重叠很少，这有力地支持了这些功能单元的真实性。
