Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, 20892, USA.
Nat Commun. 2022 Oct 21;13(1):6263. doi: 10.1038/s41467-022-34018-w.
The sensory cortices of many mammals are often organized into modules in the form of cortical columns, yet whether modular organization at this spatial scale is a general property of the human neocortex is unknown. The strongest evidence for modularity arises when measures of connectivity, structure, and function converge. Here we use microelectrode recordings in humans to examine functional connectivity and neuronal spiking responses in order to assess modularity in submillimeter scale networks. We find that the human temporal lobe consists of temporally persistent spatially compact modules approximately 1.3mm in diameter. Functionally, the information coded by single neurons during an image categorization task is more similar for neurons belonging to the same module than for neurons from different modules. The geometry, connectivity, and spiking responses of these local cortical networks provide converging evidence that the human temporal lobe is organized into functional modules at the micro scale.
许多哺乳动物的感觉皮层通常以皮质柱的形式组织成模块，但在这个空间尺度上的模块组织是否是人类新皮层的普遍特性尚不清楚。当连接性、结构和功能的测量结果趋于一致时，模块性的最强证据就出现了。在这里，我们使用人类微电极记录来检查功能连接和神经元尖峰反应，以评估亚毫米尺度网络中的模块性。我们发现，人类的颞叶由大约 1.3 毫米直径的时间持久的空间紧凑模块组成。在功能上，在图像分类任务中，单个神经元编码的信息对于属于同一模块的神经元比属于不同模块的神经元更为相似。这些局部皮质网络的几何形状、连接和尖峰反应提供了一致的证据，表明人类颞叶在微观尺度上组织成功能模块。
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