Mardiak J, Sálek T, Sycova-Milá Z, Sufliarsky J, Baláz M, Koza I
Department of Medicine, National Cancer Institute, Bratislava, Slovak Republic.
Neoplasma. 2000;47(4):244-7.
Cisplatin-based chemotherapy is highly effective in advanced seminoma, but at the cost of a considerable toxicity. The response rate of carboplatin is comparable with cisplatin combinations but the relapse rate is higher. Our study assesses the efficacy and the toxicity of the combination of carboplatin and cyclophosphamide in patients with advanced seminoma. Nineteen consecutive patients received 6 cycles of intravenous cyclophosphamide 750 mg/m2 and carboplatin 350 mg/m2, repeated every 21 days. The overall objective response rate was 100%, 11 patients (58%) achieved a complete response and 8 patients (42%) showed a partial response. At median follow up of 4.2 years 3 patients (15%) relapsed. The 2-year disease-free survival and the overall survival are 72 and 94%, respectively. This outpatient treatment was well tolerated and the toxicity was mild. One patient had granulocytopenic fever and one patient had grade 3 cystitis. The combination therapy with carboplatin and cyclophosphamide is an effective and tolerable regimen in advanced seminoma.
基于顺铂的化疗对晚期精原细胞瘤非常有效，但代价是具有相当大的毒性。卡铂的缓解率与顺铂联合用药相当，但复发率更高。我们的研究评估了卡铂和环磷酰胺联合用药对晚期精原细胞瘤患者的疗效和毒性。19例连续患者接受了6个周期的静脉注射环磷酰胺750mg/m²和卡铂350mg/m²，每21天重复一次。总体客观缓解率为100%，11例患者（58%）达到完全缓解，8例患者（42%）显示部分缓解。在中位随访4.2年时，3例患者（15%）复发。2年无病生存率和总生存率分别为72%和94%。这种门诊治疗耐受性良好，毒性轻微。1例患者出现粒细胞缺乏性发热，1例患者出现3级膀胱炎。卡铂和环磷酰胺联合治疗是晚期精原细胞瘤一种有效且可耐受的方案。
