Troyanova P, Valerianova Z, Danon S
National Oncological Center, Sofia, Bulgaria.
Neoplasma. 2000;47(4):257-60.
The aim of the study was to investigate the distribution of the newly diagnosed cases with cutaneous malignant melanoma by clinical stages in Bulgaria over the period 1993-1995 as a reason for improving both mclanoma prevention and control. Over the period 827 new cases with cutaneous malignant melanoma are registered in the country. A representative sample of 671 cases has been taken. The cases with a localized melanoma (Stage I and II) were prevalent - 509 (75.8% of all studied cases). The thick melanomas (Stage IIB) were most frequently encountered among the primary lesions. They were 207 cases (30.8%). The thin melanomas (Stage IA) were only 41 (6.1%). The proportion of the cases with nodal and in-transit metastases (Stage III) -122 (18.2%) and the proportion of the cases with distant metastases (Stage IV) -40 (6.0%) were quite high. The analysis of the results shows that the cases with cutaneous malignant melanoma in Bulgaria are detected quite late. The cases with early-diagnosed melanoma are prevalent among women, young persons and urban population, and the cases with advanced melanoma are more frequent among men, persons older than 50 and rural population.
该研究的目的是调查1993 - 1995年期间保加利亚新诊断的皮肤恶性黑色素瘤病例按临床分期的分布情况，以此作为改善黑色素瘤预防和控制工作的依据。在此期间，该国共登记了827例新的皮肤恶性黑色素瘤病例。选取了671例具有代表性的样本。局限性黑色素瘤（I期和II期）病例居多，有509例（占所有研究病例的75.8%）。原发性病变中最常见的是厚黑色素瘤（IIB期），有207例（30.8%）。薄黑色素瘤（IA期）仅有41例（6.1%）。有淋巴结和途中转移的病例（III期）占122例（18.2%），有远处转移的病例（IV期）占40例（6.0%），这一比例相当高。结果分析表明，保加利亚的皮肤恶性黑色素瘤病例发现得相当晚。早期诊断的黑色素瘤病例在女性、年轻人和城市人口中居多，而晚期黑色素瘤病例在男性、50岁以上人群和农村人口中更为常见。
