Ndour M, Sow P S, Coll-Seck A M, Badiane S, Ndour C T, Diakhaté N, Diop B, Faye M, Soumaré M, Diouf G, Colebunders R
Department of Infectious Diseases, Fann Hospital, Dakar, Senegal; UNAIDS, WHO, Geneva, Switzerland.
Trop Med Int Health. 2000 Oct;5(10):687-91. doi: 10.1046/j.1365-3156.2000.00627.x.
To compare the clinical manifestations observed in AIDS patients infected with HIV2 and HIV1 infection.
The medical records of AIDS patients hospitalized between January 1986 and July 1997 at the Department of Infectious Diseases of Fann Hospital, Dakar, were reviewed.
599 hospitalizations (76%) were HIV1 seropositive patients, 137 (17%) were HIV2 seropositive patients and 54 (7%) were patients serologically dually reactive to HIV1 and HIV2. There was no significant difference in medium CD4 lymphocyte count between patients with HIV1 and HIV2 infection. Chronic diarrhoea and diarrhoea caused by bacterial infections were more frequently observed in HIV2-infected individuals. Oral candidiasis and chronic fever were more often noted in patients with HIV1 infection. Bacterial and cryptococcal meningitis was only observed among patients with HIV1 infection.
Certain clinical differences were observed comparing AIDS patients with HIV1 and those with HIV2 infection. As there is no clear physiopathological explanation for these differences, additional studies with larger numbers of AIDS patients are needed to determine whether these differences are real.
比较感染HIV-2和HIV-1的艾滋病患者的临床表现。
回顾了1986年1月至1997年7月在达喀尔法恩医院传染病科住院的艾滋病患者的病历。
599例住院患者（76%）为HIV-1血清学阳性患者，137例（17%）为HIV-2血清学阳性患者，54例（7%）为HIV-1和HIV-2血清学双重反应性患者。HIV-1和HIV-2感染患者的平均CD4淋巴细胞计数无显著差异。HIV-2感染个体中慢性腹泻和细菌感染引起的腹泻更为常见。HIV-1感染患者中口腔念珠菌病和慢性发热更为常见。细菌性和隐球菌性脑膜炎仅在HIV-1感染患者中观察到。
比较HIV-1和HIV-2感染的艾滋病患者时观察到了某些临床差异。由于对这些差异尚无明确的生理病理学解释，因此需要对更多艾滋病患者进行进一步研究，以确定这些差异是否真实存在。
