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尝试通过给予溶菌酶并用大肠杆菌O86抗原免疫来增强经6-巯基嘌呤治疗的小鼠的抗感染能力。

Attempt to enhance resistance to infection in 6-mercaptopurine treated mice by lysozyme administration and immunization with Escherichia coli O86 antigen.

作者信息

Prixová J

出版信息

Folia Microbiol (Praha). 1975;20(6):513-6. doi: 10.1007/BF02891712.

DOI:10.1007/BF02891712
PMID:1104427
Abstract

Long-term immunosuppressive therapy of mice with 6-mercaptopurine (6-MP) for 2 and/or 3 weeks results in partial lethality, decrease of total leukocyte count, of serum lysozyme level and in bacteremia. The adverse effect of 6-MP treatment could not be prevented by lysozyme administration; immunization with Escherichia coli O86 antigen further increased the lethality of 6-MP in mice. The results stress the potential danger of immunization with bacterial antigens during immunosuppressive therapy.

摘要

用6-巯基嘌呤（6-MP）对小鼠进行2周和/或3周的长期免疫抑制治疗会导致部分小鼠死亡、总白细胞计数降低、血清溶菌酶水平下降以及菌血症。给予溶菌酶无法预防6-MP治疗的不良反应；用大肠杆菌O86抗原免疫会进一步增加6-MP对小鼠的致死率。这些结果强调了免疫抑制治疗期间用细菌抗原免疫的潜在危险。

相似文献

1
Attempt to enhance resistance to infection in 6-mercaptopurine treated mice by lysozyme administration and immunization with Escherichia coli O86 antigen.尝试通过给予溶菌酶并用大肠杆菌O86抗原免疫来增强经6-巯基嘌呤治疗的小鼠的抗感染能力。
Folia Microbiol (Praha). 1975;20(6):513-6. doi: 10.1007/BF02891712.
2
[Effect of 6-mercaptopurine on various factors of natural resistance to infection. II. Levels of serum lysozyme and an attempt to enhance the resistance to infection through the administration of lysozyme and immunization using E.Coli 086 antigens].[6-巯基嘌呤对天然抗感染各种因素的影响。II. 血清溶菌酶水平以及通过给予溶菌酶和使用大肠杆菌O86抗原进行免疫来增强抗感染能力的尝试]
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1975;19(1):131-47.
3
Application of lysozyme and immunization with Escherichia coli 086 antigen in mice treated with 6-mercaptopurine.溶菌酶的应用及用大肠杆菌086抗原对接受6-巯基嘌呤治疗的小鼠进行免疫接种。
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1974;17(1-2):133-5.
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Serum lysozyme in mice subjected to combined immunosuppression with 6-mercaptopurine and hydrocortisone.接受6-巯基嘌呤和氢化可的松联合免疫抑制的小鼠血清溶菌酶
Folia Microbiol (Praha). 1975;20(6):509-12. doi: 10.1007/BF02891711.
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Potential use of shared antigens for immunization against gram-negative bacillary infections.
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Effects of 6-mercaptopurine treatment on sperm production and reproductive performance: a study in male mice.
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Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1974;17(1-2):130-2.
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J Clin Gastroenterol. 2003 Sep;37(3):220-5. doi: 10.1097/00004836-200309000-00006.

本文引用的文献

1
LYSOSOMES.溶酶体
Blood. 1964 Nov;24:594-606.
2
Plasma beta-lysin and lysozyme following endotoxin administration and the generalized Shwartzman reaction.内毒素给药及全身性施瓦茨曼反应后的血浆β-溶素和溶菌酶
Proc Soc Exp Biol Med. 1971 Feb;136(2):473-8. doi: 10.3181/00379727-136-35291.
3
[Active and passive immunization during immunosuppression].[免疫抑制期间的主动免疫和被动免疫]
Cas Lek Cesk. 1970 Jul;109(31):738-40.
4
Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia.单核细胞性和单核粒细胞性白血病中的血清及尿液溶菌酶（胞壁质酶）
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5
The effect of antilymphocyte serum, imuran and hydrocortisone on the development of colibacillary infection in mice.抗淋巴细胞血清、硫唑嘌呤和氢化可的松对小鼠大肠杆菌感染发展的影响。
Folia Biol (Praha). 1971;17(4):264-6.
6
[The effect of 6-mercaptopurine on the formation of antibodies against Escherichia coli 086].[6-巯基嘌呤对大肠杆菌086抗体形成的影响]
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1974;17(4 Suppl):221-30.
7
[Effect of 6-mercaptopurine on various factors of natural resistance to infection. 1. Mortality, weight, leukocytes and reticulocytes in peripheral blood].[6-巯基嘌呤对感染天然抵抗力各因素的影响。1. 外周血中的死亡率、体重、白细胞和网织红细胞]
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1975;19(1):117-30.