• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

接受6-巯基嘌呤和氢化可的松联合免疫抑制的小鼠血清溶菌酶

Serum lysozyme in mice subjected to combined immunosuppression with 6-mercaptopurine and hydrocortisone.

作者信息

Prixová J

出版信息

Folia Microbiol (Praha). 1975;20(6):509-12. doi: 10.1007/BF02891711.

DOI:10.1007/BF02891711
PMID:1193498
Abstract

Simultaneous peroral administration of 6-mercaptopurine (80 mg/kg per day) and subcutaneous injection of hydrocortisone (1 mg/mouse per day) for ten days results in increased lethality and more pronounced decrease in total peripheral leukocyte count and serum lysozyme levels as compared with mice receiving each drug separately. The possible mechanism of this effect is discussed.

摘要

连续十天同时经口给予6-巯基嘌呤(每天80毫克/千克)并皮下注射氢化可的松(每天1毫克/只小鼠),与单独接受每种药物的小鼠相比,会导致致死率增加,外周血白细胞总数和血清溶菌酶水平下降更为明显。文中讨论了这种效应可能的机制。

相似文献

1
Serum lysozyme in mice subjected to combined immunosuppression with 6-mercaptopurine and hydrocortisone.接受6-巯基嘌呤和氢化可的松联合免疫抑制的小鼠血清溶菌酶
Folia Microbiol (Praha). 1975;20(6):509-12. doi: 10.1007/BF02891711.
2
Immunosuppression with 6-mercaptopurine and hydrocortisone and serum lysozyme in mice.6-巯基嘌呤和氢化可的松对小鼠的免疫抑制作用及血清溶菌酶的研究
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1974;17(1-2):130-2.
3
Attempt to enhance resistance to infection in 6-mercaptopurine treated mice by lysozyme administration and immunization with Escherichia coli O86 antigen.尝试通过给予溶菌酶并用大肠杆菌O86抗原免疫来增强经6-巯基嘌呤治疗的小鼠的抗感染能力。
Folia Microbiol (Praha). 1975;20(6):513-6. doi: 10.1007/BF02891712.
4
Effects of various drugs on insulin antibodies.各种药物对胰岛素抗体的影响。
Br J Pharmacol. 1971 May;42(1):66-77. doi: 10.1111/j.1476-5381.1971.tb07087.x.
5
Studies on the mode of action of heterologous antilymphocyte plasma (ALP). 3. The effects of 6-mercaptopurine and cortisol on the immunosuppressive properties of ALP.异种抗淋巴细胞血浆(ALP)作用方式的研究。3. 6-巯基嘌呤和皮质醇对ALP免疫抑制特性的影响。
Transplantation. 1968 Sep;6(6):765-70. doi: 10.1097/00007890-196809000-00003.
6
[Experimental infection of mice with bacterial L forms against a background of immunodepressants].[在免疫抑制剂背景下小鼠的细菌L型实验性感染]
Zh Mikrobiol Epidemiol Immunobiol. 1974 Apr;51(4):91-4.
7
The effect of 6-mercaptopurine on the serum lysozyme levels in mice.6-巯基嘌呤对小鼠血清溶菌酶水平的影响。
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1974;17(1-2):127-9.
8
[Treatment and prevention of experimental pneumonias, caused by L forms of bacteria].[由细菌L型引起的实验性肺炎的治疗与预防]
Zh Mikrobiol Epidemiol Immunobiol. 1975 Jun(6):115-22.
9
[The serum lysozyme in chronic myeloleukosis].[慢性粒细胞白血病中的血清溶菌酶]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1970;93(2):184-95.
10
Mechanisms in immune tolerance. III. Immunosuppression and the induction of tolerance--synergism and antagonism.
Cell Immunol. 1975 May;17(1):215-27. doi: 10.1016/s0008-8749(75)80021-9.

引用本文的文献

1
Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes.单核细胞增生李斯特菌通过调节细胞壁修饰酶而非获取这些酶来抵抗溶菌酶。
J Bacteriol. 2014 Nov;196(21):3756-67. doi: 10.1128/JB.02053-14. Epub 2014 Aug 25.
2
Mutations of the Listeria monocytogenes peptidoglycan N-deacetylase and O-acetylase result in enhanced lysozyme sensitivity, bacteriolysis, and hyperinduction of innate immune pathways.李斯特菌属的肽聚糖 N-脱乙酰基酶和 O-乙酰基转移酶的突变导致溶菌酶敏感性增强、细菌裂解和先天免疫途径的过度诱导。
Infect Immun. 2011 Sep;79(9):3596-606. doi: 10.1128/IAI.00077-11. Epub 2011 Jul 18.

本文引用的文献

1
Studies on lysosomes. I. The effects of endotoxin, endotoxin tolerance, and cortisone on the release of acid hydrolases from a granular fraction of rabbit liver.溶酶体研究。I. 内毒素、内毒素耐受性及可的松对兔肝颗粒组分中酸性水解酶释放的影响
J Exp Med. 1962 Oct 1;116(4):433-50. doi: 10.1084/jem.116.4.433.
2
Serum muramidase and granulocyte turnover.血清溶菌酶与粒细胞更新
Proc Soc Exp Biol Med. 1968 Feb;127(2):365-7. doi: 10.3181/00379727-127-32692.
3
The anti-inflammatory effect of some immunosuppressive agents.一些免疫抑制剂的抗炎作用。
J Pathol. 1969 Feb;97(2):367-73. doi: 10.1002/path.1710970223.
4
Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia.单核细胞性和单核粒细胞性白血病中的血清及尿液溶菌酶(胞壁质酶)
J Exp Med. 1966 Nov 1;124(5):921-52. doi: 10.1084/jem.124.5.921.
5
Suppression of reticuloendothelial function in the rat with cyclophosphamide.用环磷酰胺抑制大鼠的网状内皮系统功能。
J Bacteriol. 1969 Oct;100(1):117-22. doi: 10.1128/jb.100.1.117-122.1969.
6
The effect of immunosuppressive therapy on serum factors involved in resistance to infection in the rat.
J Reticuloendothel Soc. 1970 Jun;7(6):705-15.
7
[Effect of 6-mercaptopurine on various factors of natural resistance to infection. 1. Mortality, weight, leukocytes and reticulocytes in peripheral blood].[6-巯基嘌呤对感染天然抵抗力各因素的影响。1. 外周血中的死亡率、体重、白细胞和网织红细胞]
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1975;19(1):117-30.