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晚期癌症。生存时间的持续时间和预测。

Terminal cancer. duration and prediction of survival time.

作者信息

Llobera J, Esteva M, Rifà J, Benito E, Terrasa J, Rojas C, Pons O, Catalán G, Avellà A

机构信息

Unitat d'Investigació, Atencic primària de Mallorca, Insalud Balears, C/Reina Esclaramunda 9, 07003, 231, Palma de Mallorca, Spain.

出版信息

Eur J Cancer. 2000 Oct;36(16):2036-43. doi: 10.1016/s0959-8049(00)00291-4.

Abstract

The duration of the terminal period of cancer allows us to determine its prevalence, which is necessary to plan palliative care services. Clinical prediction of survival influences access to palliative care and the healthcare approach to be adopted. The objective of this study was to determine the duration of the terminal period, the prognostic ability of healthcare professionals to predict this terminal period and the factors that can improve the prognostic accuracy. In the island of Mallorca, Spain, we followed 200 cancer patients at the inception of the terminal period. Twenty-one symptoms, quality of life, prognosis and duration of survival were measured. Using a Cox regression model, a predictive survival model was built. Median duration was 59 days; 95% confidence interval (CI)=49-69 days, mean=99 days. The oncologists were accurate in their predictions (+/-1/3 duration) in 25.7% of cases, the nurses in 21.5% of cases and the family physicians in 21.7% of cases. Errors of overestimation occurred 2.86-4.14 times more frequently than underestimation. In the final model, in addition to clinical prognosis (P=0.0094), asthenia (P=0.0257) and the Hebrew Rehabilitation Centre for Aged Quality of Life (HRCA-QL) Index (P=0.0002) were shown to be independent predictors of survival. In this study, the estimated duration of the terminal period was greater than that reported in a series of palliative care programmes, and survival was overestimated. Oncologists could estimate prognosis more accurately if they also take into account asthenia and HRCA-QL Index.

摘要

癌症终末期的时长有助于我们确定其患病率,这对于规划姑息治疗服务至关重要。生存的临床预测会影响姑息治疗的可及性以及所采用的医疗方法。本研究的目的是确定终末期的时长、医疗专业人员预测该终末期的预后能力以及可提高预后准确性的因素。在西班牙马略卡岛,我们在终末期开始时对200名癌症患者进行了随访。测量了21种症状、生活质量、预后和生存时长。使用Cox回归模型构建了一个预测生存模型。中位时长为59天;95%置信区间(CI)=49 - 69天,均值为99天。肿瘤学家在25.7%的病例中预测准确(±1/3时长),护士在21.5%的病例中预测准确,家庭医生在21.7%的病例中预测准确。高估误差出现的频率比低估误差高2.86 - 4.14倍。在最终模型中,除了临床预后(P = 0.0094)外,乏力(P = 0.0257)和希伯来老年康复中心生活质量(HRCA - QL)指数(P = 0.0002)被证明是生存的独立预测因素。在本研究中,终末期的估计时长大于一系列姑息治疗项目中报告的时长,且生存被高估。如果肿瘤学家还考虑乏力和HRCA - QL指数,他们可以更准确地估计预后。

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