Bishai R, Mazzotta P, Atanackovic G, Levichek Z, Pole M, Magee L A, Koren G
The Hospital for Sick Children, Toronto, Canada.
Can J Clin Pharmacol. 2000 Autumn;7(3):138-43.
Nausea and vomiting of pregnancy is the most common condition in pregnancy and affects up to 80% of all pregnant women. There are a large number of pharmacological agents that are effective for the treatment of nausea and vomiting associated with conditions such as motion sickness and gastrointestinal conditions; however, their use in pregnancy is limited by the lack of sufficient data on their potential teratogenic effects. The efficacy of the delayed-release combination of doxylamine and pyridoxine (Bendectin, Diclectin) has been shown in several randomized, controlled trials. The present review aims to refute the unsubstantiated beliefs that Diclectin is unsafe when used in the treatment of nausea and vomiting of pregnancy.
妊娠恶心和呕吐是孕期最常见的情况，影响多达80%的孕妇。有大量药物可有效治疗与晕动病和胃肠道疾病等相关的恶心和呕吐；然而，由于缺乏关于其潜在致畸作用的充分数据，它们在孕期的使用受到限制。多西拉敏和吡哆醇的缓释组合（敏克静、Diclectin）的疗效已在多项随机对照试验中得到证实。本综述旨在反驳关于Diclectin用于治疗妊娠恶心和呕吐不安全的毫无根据的观点。
