通过抗胸腺细胞血清治疗延长感染委内瑞拉马脑炎病毒致死的小鼠的平均死亡时间。
Extension of the mean time to death of mice with a lethal infection of Venezuelan equine encephalomyelitis virus by antithymocyte serum treatment.
作者信息
Woodman D R, McManus A T, Eddy G A
出版信息
Infect Immun. 1975 Nov;12(5):1006-11. doi: 10.1128/iai.12.5.1006-1011.1975.
The mean time to death of mice infected with Venezuelan equine encephalomyelitis (VEE) virus was increased 2 days by antithymocyte serum (ATS) treatment given 1 day before and 1 day after virus inoculation. Virus assays of blood, brain, and spleen indicated that VEE virus replication was delayed by ATS. Additionally, mice treated with ATS exhibited neurological signs later than untreated mice. During the infection, the percentage of splenic B lymphocytes as determined by surface immunoglobulin staining increased. ATS treatment caused a further elevation of the percentage of splenic B lymphocytes. These results show a selective depletion of the non-immunoglobulin-bearing lymphocyte population during VEE virus infection and support the hypothesis that ATS destroys or alters an important population of cells associated with the normal course of pathogenesis and the replication of VEE virus to high titers in the mouse.
在接种委内瑞拉马脑炎（VEE）病毒前1天及接种后1天给予抗胸腺细胞血清（ATS）治疗，可使感染该病毒的小鼠平均死亡时间延长2天。对血液、脑和脾脏进行病毒检测表明，ATS可延迟VEE病毒的复制。此外，接受ATS治疗的小鼠出现神经症状的时间比未治疗的小鼠晚。在感染过程中，通过表面免疫球蛋白染色测定的脾脏B淋巴细胞百分比增加。ATS治疗使脾脏B淋巴细胞百分比进一步升高。这些结果表明，在VEE病毒感染期间，不携带免疫球蛋白的淋巴细胞群体被选择性消耗，并支持以下假说：ATS破坏或改变了与发病机制正常进程以及VEE病毒在小鼠体内高滴度复制相关的重要细胞群体。
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