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1
Extension of the mean time to death of mice with a lethal infection of Venezuelan equine encephalomyelitis virus by antithymocyte serum treatment.通过抗胸腺细胞血清治疗延长感染委内瑞拉马脑炎病毒致死的小鼠的平均死亡时间。
Infect Immun. 1975 Nov;12(5):1006-11. doi: 10.1128/iai.12.5.1006-1011.1975.
2
Persistence in humans of antibody to subtypes of Venezuelan equine encephalomyelitis (VEE) virus after immunization with attenuated (TC-83) VEE virus vaccine.用减毒委内瑞拉马脑炎（VEE）病毒疫苗（TC-83）免疫后，人类体内针对VEE病毒亚型抗体的持久性。
J Infect Dis. 1977 Sep;136(3):354-9. doi: 10.1093/infdis/136.3.354.
3
Kinetics of cytokine expression and regulation of host protection following infection with molecularly cloned Venezuelan equine encephalitis virus.分子克隆的委内瑞拉马脑炎病毒感染后细胞因子表达动力学及宿主保护调节
Virology. 1997 Jul 7;233(2):302-12. doi: 10.1006/viro.1997.8617.
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Rapid diagnosis of Venezuelan equine encephalomyelitis by fluorescence microscopy.通过荧光显微镜术快速诊断委内瑞拉马脑脊髓炎
Am J Vet Res. 1975 Feb;36(2):167-70.
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In mice the efficiency of immunization with Venezuelan Equine Encephalomyelitis virus TC-83 is transiently increased by dehydroepiandrosterone.在小鼠中，脱氢表雄酮可使委内瑞拉马脑炎病毒TC-83的免疫效率短暂提高。
Invest Clin. 2001 Dec;42(4):235-40.
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Recombinant vaccinia virus/Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge.重组痘苗病毒/委内瑞拉马脑炎（VEE）病毒可保护小鼠免受外周VEE病毒攻击。
J Virol. 1988 Dec;62(12):4697-702. doi: 10.1128/JVI.62.12.4697-4702.1988.
7
Venezuelan equine encephalitis virus vaccines induce mucosal IgA responses and protection from airborne infection in BALB/c, but not C3H/HeN mice.委内瑞拉马脑炎病毒疫苗可诱导BALB/c小鼠产生黏膜IgA反应并使其免受空气传播感染的侵害，但对C3H/HeN小鼠无效。
Vaccine. 1997 Mar;15(4):363-9. doi: 10.1016/s0264-410x(96)00204-6.
8
Modification of Venezuelan equine encephalomyelitis virus infection in mice by X radiation.X射线对小鼠委内瑞拉马脑炎病毒感染的影响
Am J Vet Res. 1977 Sep;38(9):1413-9.
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Cross-protective immunity between equine encephalomyelitis viruses in equids.马属动物中马脑脊髓炎病毒之间的交叉保护性免疫。
Am J Vet Res. 1989 Sep;50(9):1442-6.
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Induction of protective immune responses against Venezuelan equine encephalitis (VEE) virus aerosol challenge with microencapsulated VEE virus vaccine.用微囊化委内瑞拉马脑炎（VEE）病毒疫苗诱导针对VEE病毒气溶胶攻击的保护性免疫反应。
Vaccine. 1998 Aug;16(13):1314-23. doi: 10.1016/s0264-410x(98)00008-5.

引用本文的文献

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Adv Virus Res. 2020;107:315-382. doi: 10.1016/bs.aivir.2020.06.002. Epub 2020 Jul 8.
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Bioluminescent imaging and histopathologic characterization of WEEV neuroinvasion in outbred CD-1 mice.在远交 CD-1 小鼠中观察 WEEV 神经入侵的生物发光成像和组织病理学特征。
PLoS One. 2013;8(1):e53462. doi: 10.1371/journal.pone.0053462. Epub 2013 Jan 2.
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Active immunization by a dengue virus-induced cytokine.由登革病毒诱导的细胞因子进行的主动免疫
Clin Exp Immunol. 1994 May;96(2):202-7. doi: 10.1111/j.1365-2249.1994.tb06542.x.
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Mechanisms of protective immunogenicity of microbial vaccines: effects of cyclophosphamide pretreatment in Venezuelan encephalitis, Q fever and tularaemia.微生物疫苗的保护性免疫原性机制：环磷酰胺预处理对委内瑞拉马脑炎、Q热和兔热病的影响。
Clin Exp Immunol. 1980 Aug;41(2):225-36.
5
Infections of congenitally athymic (nude) and normal mice with avirulent and virulent strains of Venezuelan encephalitis virus.用委内瑞拉脑炎病毒的无毒株和有毒株感染先天性无胸腺（裸）小鼠和正常小鼠。
Infect Immun. 1978 Sep;21(3):779-85. doi: 10.1128/iai.21.3.779-785.1978.

本文引用的文献

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FATAL ENCEPHALITIS IN MAN DUE TO THE VENEZUELAN VIRUS OF EQUINE ENCEPHALOMYELITIS IN TRINIDAD.特立尼达岛因委内瑞拉马脑脊髓炎病毒导致的人类致命性脑炎。
Science. 1944 Mar 17;99(2568):225-6. doi: 10.1126/science.99.2568.225.
2
The comparative pathology of experimental Venezuelan equine encephalomyelitis infection in different animal hosts.不同动物宿主中实验性委内瑞拉马脑炎感染的比较病理学
J Infect Dis. 1962 Jan-Feb;110:80-97. doi: 10.1093/infdis/110.1.80.
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The comparative pathology of Venezuelan equine encephalomyelitis.委内瑞拉马脑炎的比较病理学
J Infect Dis. 1956 Jan-Feb;98(1):55-66. doi: 10.1093/infdis/98.1.55.
4
Elimination of repeated clot formation in mouse ascitic fluid containing arbovirus antibodies.消除含有虫媒病毒抗体的小鼠腹水中反复形成的凝块。
Appl Microbiol. 1972 Aug;24(2):288-9. doi: 10.1128/am.24.2.288-289.1972.
5
Lymphocyte surface immunoglobulins. Distribution and frequency in lymphoproliferative diseases.淋巴细胞表面免疫球蛋白。在淋巴增殖性疾病中的分布及频率
N Engl J Med. 1973 Jan 25;288(4):176-80. doi: 10.1056/NEJM197301252880403.
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Surface markers on lymphocytes of patients with infectious diseases.传染病患者淋巴细胞表面标志物
Infect Immun. 1973 Jul;8(1):110-7. doi: 10.1128/iai.8.1.110-117.1973.
7
Participation of lymphocytes in viral infections.淋巴细胞在病毒感染中的作用。
Adv Immunol. 1973;16:123-84. doi: 10.1016/s0065-2776(08)60297-7.
8
Immunoglobulins on the surface of neoplastic lymphocytes.肿瘤淋巴细胞表面的免疫球蛋白。
N Engl J Med. 1972 Aug 10;287(6):272-6. doi: 10.1056/NEJM197208102870603.
9
Effects of antithymocyte serum and antilymphocyte serum on the postnatal development of the thymolymphatic system in BALB-C mice.抗胸腺细胞血清和抗淋巴细胞血清对BALB-C小鼠胸腺淋巴系统出生后发育的影响。
J Reticuloendothel Soc. 1973 Jan;13(1):78-89.
10
Disturbance of the blood T:B lymphocyte ratio in lepromatous leprosy. Clinical and immunologic correlations.瘤型麻风患者血液中T淋巴细胞与B淋巴细胞比例的紊乱。临床与免疫学相关性
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通过抗胸腺细胞血清治疗延长感染委内瑞拉马脑炎病毒致死的小鼠的平均死亡时间。

Extension of the mean time to death of mice with a lethal infection of Venezuelan equine encephalomyelitis virus by antithymocyte serum treatment.

作者信息

Woodman D R, McManus A T, Eddy G A

出版信息

Infect Immun. 1975 Nov;12(5):1006-11. doi: 10.1128/iai.12.5.1006-1011.1975.

DOI:10.1128/iai.12.5.1006-1011.1975
PMID:1104481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC415389/
Abstract

The mean time to death of mice infected with Venezuelan equine encephalomyelitis (VEE) virus was increased 2 days by antithymocyte serum (ATS) treatment given 1 day before and 1 day after virus inoculation. Virus assays of blood, brain, and spleen indicated that VEE virus replication was delayed by ATS. Additionally, mice treated with ATS exhibited neurological signs later than untreated mice. During the infection, the percentage of splenic B lymphocytes as determined by surface immunoglobulin staining increased. ATS treatment caused a further elevation of the percentage of splenic B lymphocytes. These results show a selective depletion of the non-immunoglobulin-bearing lymphocyte population during VEE virus infection and support the hypothesis that ATS destroys or alters an important population of cells associated with the normal course of pathogenesis and the replication of VEE virus to high titers in the mouse.

摘要

在接种委内瑞拉马脑炎（VEE）病毒前1天及接种后1天给予抗胸腺细胞血清（ATS）治疗，可使感染该病毒的小鼠平均死亡时间延长2天。对血液、脑和脾脏进行病毒检测表明，ATS可延迟VEE病毒的复制。此外，接受ATS治疗的小鼠出现神经症状的时间比未治疗的小鼠晚。在感染过程中，通过表面免疫球蛋白染色测定的脾脏B淋巴细胞百分比增加。ATS治疗使脾脏B淋巴细胞百分比进一步升高。这些结果表明，在VEE病毒感染期间，不携带免疫球蛋白的淋巴细胞群体被选择性消耗，并支持以下假说：ATS破坏或改变了与发病机制正常进程以及VEE病毒在小鼠体内高滴度复制相关的重要细胞群体。