弓形虫热休克蛋白70作为弓形虫感染小鼠中的一种危险信号
Toxoplasma gondii Hsp70 as a danger signal in toxoplasma gondii-infected mice.
作者信息
Mun H S, Aosai F, Norose K, Chen M, Hata H, Tagawa Y I, Iwakura Y, Byun D S, Yano A
机构信息
Department of Parasitology, Chiba University School of Medicine, Japan.
出版信息
Cell Stress Chaperones. 2000 Oct;5(4):328-35. doi: 10.1379/1466-1268(2000)005<0328:tghaad>2.0.co;2.
Abstract
Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-gamma knockout mice infected with T gondii. Tgondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.
摘要
弓形虫热休克蛋白70（Toxoplasma gondii Hsp70）、弓形虫热休克蛋白30/袋蛋白1（T gondii Hsp30/bag1）和表面抗原1信使核糖核酸被证明在分析弓形虫在缓殖子和速殖子之间的阶段转换中很有用。弓形虫热休克蛋白70的高水平表达与感染弓形虫的干扰素-γ基因敲除小鼠的死亡率相关。弓形虫热休克蛋白70抑制弓形虫感染小鼠腹腔巨噬细胞一氧化氮释放的诱导。这些发现确定弓形虫热休克蛋白70是致死性急性弓形虫感染期间的一种危险信号。
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