Usta I M, Sibai B M, Mercer B M, Kreamer B L, Gourley G R
Department of Obstetrics and Gynecology, University of Tennessee, Memphis, USA.
J Matern Fetal Med. 2000 Jul-Aug;9(4):201-3. doi: 10.1002/1520-6661(200007/08)9:4<201::AID-MFM2>3.0.CO;2-L.
To evaluate the usefulness of maternal plasma zinc-coproporphyrin (ZCP) level as a marker for intrauterine passage of meconium.
A pilot study consisting of 10 pregnancies with meconium-stained amniotic fluid and 10 pregnancies with clear amniotic fluid was used. The corresponding plasma and amniotic fluid levels of ZCP were measured using spectrofluorometry. ZCP levels in plasma and amniotic fluid were compared between the two groups and the relation between plasma and amniotic fluid ZCP levels in the clear and meconium-stained groups was assessed using Spearman rank-order correlation.
Mean amniotic fluid ZCP was significantly higher in the meconium-stained amniotic fluid as compared to the clear amniotic fluid group. Although mean plasma ZCP levels were higher in the meconium-stained amniotic fluid group, this difference was not statistically significant. There was no significant correlation between plasma ZCP levels and amniotic fluid ZCP, but we could categorize patients according to plasma ZCP levels into four categories with different risks for having meconium-stained amniotic fluid.
Plasma ZCP might be a promising test for prediction of intrauterine passage of meconium in high-risk patients if confirmed by larger studies. The implications of this prediction on management remain unknown.
评估母体血浆锌原卟啉（ZCP）水平作为胎粪宫内排出标志物的有效性。
采用一项前瞻性研究，其中包括10例羊水粪染妊娠和10例羊水清亮妊娠。使用荧光分光光度法测量相应的血浆和羊水ZCP水平。比较两组之间血浆和羊水ZCP水平，并使用Spearman等级相关评估清亮组和粪染组中血浆和羊水ZCP水平之间的关系。
与羊水清亮组相比，羊水粪染组的平均羊水ZCP显著更高。虽然羊水粪染组的平均血浆ZCP水平更高，但这种差异无统计学意义。血浆ZCP水平与羊水ZCP之间无显著相关性，但我们可根据血浆ZCP水平将患者分为四类，其羊水粪染风险不同。
如果大型研究证实，血浆ZCP可能是预测高危患者胎粪宫内排出的一项有前景的检测方法。这种预测对管理的影响尚不清楚。
