Andrä W, Danan H, Kirmsse W, Kramer H H, Saupe P, Schmieg R, Bellemann M E
Institute for Physical High Technology, Jena, Germany.
Phys Med Biol. 2000 Oct;45(10):3081-93. doi: 10.1088/0031-9155/45/10/322.
In internal medicine, a simple method for the functional examination of the gastrointestinal tract without the risk of radiation exposure is required. We describe a novel principle based on the monitoring of magnetic markers which meets these demands. Our method employs a special permanent magnet which is repeatedly aligned by a vertically oriented pulsed magnetic field. Due to this alignment, the marker position can be derived from the stray field components measured by commercial field sensors. Our method was evaluated by means of a 3D intestinal phantom. The monitoring procedure yielded the time course of the marker position as a 3D plot either in real-time or as a time-lapse movie. The spatial resolution, expressed by the mean square deviation, was better than 10 mm and is thus sufficiently high to distinguish between adjacent loops of the gut. The temporal resolution, i.e. the minimum time between two successive measurements, was about 1 s. The presented method has very moderate technical demands and allows us to monitor magnetic markers in real-time. The technique may be useful with respect to functional examination of the gastrointestinal tract. In pharmaceutical research, our method offers the opportunity for remote drug release at any position of the gut.
在内科医学中，需要一种用于胃肠道功能检查的简单方法，且不存在辐射暴露风险。我们描述了一种基于监测磁性标记物的新原理，该原理满足这些要求。我们的方法采用一种特殊的永久磁铁，它由垂直方向的脉冲磁场反复对齐。由于这种对齐，标记物的位置可以从商用磁场传感器测量的杂散场分量中推导出来。我们的方法通过一个三维肠道模型进行了评估。监测过程以三维图的形式实时或作为延时电影给出标记物位置的时间进程。以均方偏差表示的空间分辨率优于10毫米，因此足够高以区分肠道相邻的肠袢。时间分辨率，即两次连续测量之间的最短时间，约为1秒。所提出的方法技术要求非常适中，并允许我们实时监测磁性标记物。该技术对于胃肠道功能检查可能是有用的。在药物研究中，我们的方法为在肠道的任何位置进行远程药物释放提供了机会。
