Funseth E, Lindh U, Wesslén L, Friman G, Ilbäck N G
Department of Medical Sciences, Uppsala University Hospital, Sweden.
Biol Trace Elem Res. 2000 Aug;76(2):149-60. doi: 10.1385/BTER:76:2:149.
During most infections plasma, concentrations of trace elements change, but it is unclear if this reflects changes in infected target tissues. In coxsackievirus B3 (CB3) infection, the myocardium is a target in both humans and mice. The concentrations of 12 trace elements were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) in the myocardium of sham-inoculated controls and infected A/J mice 4 and 7 d postinoculation. The size of the inflammatory lesion was positively correlated to the virus content of the heart, as estimated by histopathology and in situ hybridization, respectively. Iron, cobalt, vanadium, and selenium showed transient changes, whereas for the other elements, tendencies on d 4 were manifest on d 7. A three-fold increase in calcium on d 7 suggests prestages of calcification, whereas increases in zinc, selenium, and copper may be the result of the accumulation of immune cells. The magnesium decrease may contribute to the increased sensitivity to cardiac arrhythmias in myocarditis.
在大多数感染过程中，血浆中微量元素的浓度会发生变化，但尚不清楚这是否反映了受感染靶组织中的变化。在柯萨奇病毒B3（CB3）感染中，心肌是人类和小鼠的靶器官。通过电感耦合等离子体质谱法（ICP-MS）分析了假接种对照小鼠以及接种后4天和7天的感染A/J小鼠心肌中12种微量元素的浓度。通过组织病理学和原位杂交分别估计，炎性病变的大小与心脏的病毒含量呈正相关。铁、钴、钒和硒呈现出短暂变化，而对于其他元素，第4天的变化趋势在第7天更为明显。第7天钙增加三倍表明存在钙化前期，而锌、硒和铜的增加可能是免疫细胞积累的结果。镁含量降低可能导致心肌炎时对心律失常的敏感性增加。
