Whitworth J A, Fairley K F, O'Keefe C M, Miller T E
Kidney Int. 1975 Nov;8(5):316-9. doi: 10.1038/ki.1975.118.
The role of immunogenicity of the infecting organism (Escherichia coli) in the antibody response to O antigen in upper urinary tract infection was investigated. Heat-killed vaccines were prepared from "immunogenic" organisms which had produced upper urinary tract infection associated with high titers of hemagglutinating antibody to O antigen and "nonimmunogenic" organisms which had produced upper urinary tract infection without a rise in antibody titer. "Immunogenic" 06 vaccine produced high titers of antibody in patients regarded as possibly "poor producers" of antibody, but "nonimmunogenic" 011 vaccine was not associated with a rise in titer in patients previously regarded as "good producers". These vaccines were significantly different in immunogenicity (P less than 0.05). Five vaccines were tested in 50 rats. The difference in hemagglutinating titers to O antigen between 06 and 011 was highly significant (P less than 0.001). Immunogenicity of the infecting organism appears to be a significant factor in determining antibody response to O antigen in upper tract infection.
研究了感染病原体（大肠杆菌）的免疫原性在上尿路感染中对O抗原抗体反应的作用。热灭活疫苗是由产生与高滴度O抗原血凝抗体相关的上尿路感染的“免疫原性”病原体和产生上尿路感染但抗体滴度未升高的“非免疫原性”病原体制备而成。“免疫原性”O6疫苗在被认为可能是抗体“低产生者”的患者中产生了高滴度抗体，但“非免疫原性”O11疫苗在先前被认为是抗体“高产生者”的患者中并未导致滴度升高。这些疫苗在免疫原性上有显著差异（P小于0.05）。在50只大鼠中测试了五种疫苗。O6和O11之间对O抗原的血凝滴度差异非常显著（P小于0.001）。感染病原体的免疫原性似乎是决定上尿路感染中对O抗原抗体反应的一个重要因素。
