Straube E, Nimmich W, Broschewitz U, Naumann G, Hacker K
Institute of Microbiology, Medical School of the Wilhelm Pieck University, Rostock, GDR.
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Jul;265(3-4):408-19. doi: 10.1016/s0176-6724(87)80260-2.
The influence of vaccination with an immunogenic K1 antigen of Escherichia coli on the course of pyelonephritis induced experimentally in rats by infection with Escherichia coli O2:K1:H4 was investigated. The immunogenic properties of K1 antigen are poor. A conjugate of K1 antigen with bovine serum albumin (BSA) was therefore tested. Preliminary experiments showed that the K1-BSA conjugate is immunogenic. Renal inflammatory activity in rats after retrograde infection was significantly reduced after vaccination of the animals with K1-BSA conjugate within six weeks of infection.
研究了用大肠杆菌免疫原性K1抗原接种对大鼠经大肠杆菌O2:K1:H4感染实验诱导的肾盂肾炎病程的影响。K1抗原的免疫原性较差。因此测试了K1抗原与牛血清白蛋白（BSA）的结合物。初步实验表明，K1-BSA结合物具有免疫原性。在感染六周内用K1-BSA结合物给动物接种后，逆行感染大鼠的肾脏炎症活性显著降低。
