用大肠杆菌K1抗原免疫对大鼠尿道实验性感染病程的影响。
Effect of immunization with Escherichia coli K1 antigen on the course of experimental infection of the urinary tract of the rat.
作者信息
Straube E, Nimmich W, Broschewitz U, Naumann G, Hacker K
机构信息
Institute of Microbiology, Medical School of the Wilhelm Pieck University, Rostock, GDR.
出版信息
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Jul;265(3-4):408-19. doi: 10.1016/s0176-6724(87)80260-2.
The influence of vaccination with an immunogenic K1 antigen of Escherichia coli on the course of pyelonephritis induced experimentally in rats by infection with Escherichia coli O2:K1:H4 was investigated. The immunogenic properties of K1 antigen are poor. A conjugate of K1 antigen with bovine serum albumin (BSA) was therefore tested. Preliminary experiments showed that the K1-BSA conjugate is immunogenic. Renal inflammatory activity in rats after retrograde infection was significantly reduced after vaccination of the animals with K1-BSA conjugate within six weeks of infection.
研究了用大肠杆菌免疫原性K1抗原接种对大鼠经大肠杆菌O2:K1:H4感染实验诱导的肾盂肾炎病程的影响。K1抗原的免疫原性较差。因此测试了K1抗原与牛血清白蛋白（BSA）的结合物。初步实验表明，K1-BSA结合物具有免疫原性。在感染六周内用K1-BSA结合物给动物接种后，逆行感染大鼠的肾脏炎症活性显著降低。
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