孕期尿前列腺素排泄：饮食限钠的影响。
Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction.
作者信息
Delemarre F M, Thomas C M, van den Berg R J, Jongsma H W, Steegers E A
机构信息
Department of Obstetrics and Gynecology, University Medical Center Nijmegen, The Netherlands.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2000 Oct;63(4):209-15. doi: 10.1054/plef.2000.0211.
INTRODUCTION
Dietary sodium restriction results in activation of the renin-angiotensin-aldosterone-system. In the non-pregnant situation renin release in response to a low sodium diet is mediated by prostaglandins. We studied the effect of dietary sodium restriction on urinary prostaglandin metabolism in pregnancy.
PATIENTS AND METHODS
In a randomized, longitudinal study the excretion of urinary metabolites of prostacyclin (6-keto-PGF(1 alpha)and 2,3-dinor-6-keto-PGF(1 alpha)) and thromboxane A(2)(TxB(2)and 2,3-dinor-TxB(2)) was determined throughout pregnancy and post partum in 12 women on a low sodium diet and in 12 controls.
RESULTS
In pregnancy the excretion of all urinary prostaglandins is increased. The 6-keto-PGF(1 alpha)/ TxB(2)-ratio as well as the 2, 3-dinor-6-keto-PGF(1 alpha)/ 2,3-dinor-TxB(2)-ratio did not significantly change in pregnancy. CONCLUISION Prostacyclin and thromboxane do not seem to play an important role in sodium balance during pregnancy.
引言
饮食中限制钠摄入会导致肾素 - 血管紧张素 - 醛固酮系统激活。在非孕期，低钠饮食引起的肾素释放由前列腺素介导。我们研究了孕期饮食中限制钠摄入对尿前列腺素代谢的影响。
患者与方法
在一项随机纵向研究中，测定了12名低钠饮食女性和12名对照者在整个孕期及产后尿中前列环素代谢产物（6 - 酮 - PGF(1α)和2,3 - 二去甲 - 6 - 酮 - PGF(1α)）以及血栓素A(2)（TxB(2)和2,3 - 二去甲 - TxB(2)）的排泄情况。
结果
孕期所有尿前列腺素的排泄均增加。孕期6 - 酮 - PGF(1α)/TxB(2)比值以及2,3 - 二去甲 - 6 - 酮 - PGF(1α)/2,3 - 二去甲 - TxB(2)比值无显著变化。结论：前列环素和血栓素在孕期钠平衡中似乎不起重要作用。
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