Verity R, Prasad E, Grimsrud K, Artsob H, Drebot M, Miedzinski L, Preiksaitis J
Provincial Laboratory of Public Health for Northern Alberta, University of Alberta, Edmonton, Alberta, Canada.
Clin Infect Dis. 2000 Oct;31(4):942-6. doi: 10.1086/318137. Epub 2000 Oct 25.
We reviewed the clinical and laboratory findings for 19 cases of hantavirus pulmonary syndrome (HPS) identified either serologically or by immunohistochemical testing of archival tissue at our tertiary care center. Fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms. The most prevalent presenting signs were respiratory abnormalities (95%) and tachycardia (84%). Common laboratory findings included thrombocytopenia (95%) and leukocytosis (79%). Elevated aspartate aminotransferase and lactate dehydrogenase levels were found in all patients tested. Intubation was required in 58% of the patients, and inotropic support was required in 53%. Our study confirms that serological responses appear early during clinical illness, making the enzyme immunoassay a useful tool for the diagnosis of acute HPS. The mortality (26%) and severity of disease that we observed among patients with HPS appear to be less than those reported elsewhere.
我们回顾了在我们的三级医疗中心通过血清学或对存档组织进行免疫组化检测确诊的19例汉坦病毒肺综合征（HPS）患者的临床和实验室检查结果。发热（95%）、咳嗽（89%）和呼吸困难（89%）是最常见的首发症状。最常见的体征是呼吸异常（95%）和心动过速（84%）。常见的实验室检查结果包括血小板减少（95%）和白细胞增多（79%）。所有接受检测的患者均发现天冬氨酸转氨酶和乳酸脱氢酶水平升高。58%的患者需要插管，53%的患者需要使用血管活性药物支持。我们的研究证实，血清学反应在临床疾病早期就会出现，这使得酶免疫测定成为诊断急性HPS的有用工具。我们观察到的HPS患者的死亡率（26%）和疾病严重程度似乎低于其他地方报道的情况。
