盐酸胍诱导酿酒酵母中ρ-突变体。II. 防止ρ-诱导的条件。
Induction of rho- mutants in Saccharomyces cerevisiae by guanidine hydrochloride. II. Conditions that prevent rho- induction.
作者信息
Juliani M H, Da Costa S O
出版信息
Mutat Res. 1975 Dec;30(3):335-42.
The induction of rho- "petite" mutants by guanidine hydrochloride (GuHCl) is inhibited in several conditions. Anaerobiosis inhibited the induction either with or without cell multiplication. Both nalidixic acid (NA) and cycloheximide (CH) inhibited the induction of mutants. On the other hand, chloramphenicol (CAP) produced a dual effect: at low concentration it stimulated, at high concentration it inhibited, the induction. The effect of these different inhibitors on the transformation of rho+ mother cells into rho- by GuHCl is discussed.
盐酸胍（GuHCl）诱导rho-“小菌落”突变体的过程在几种条件下受到抑制。无论有无细胞增殖，厌氧状态均会抑制诱导过程。萘啶酸（NA）和环己酰亚胺（CH）均抑制突变体的诱导。另一方面，氯霉素（CAP）产生了双重效应：低浓度时刺激诱导，高浓度时抑制诱导。文中讨论了这些不同抑制剂对GuHCl介导的rho+母细胞向rho-细胞转化的影响。
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