Yoshimasu K, Liu Y, Kodama H, Sasazuki S, Washio M, Tanaka K, Tokunaga S, Kono S, Arai H, Koyanagi S, Hiyamuta K, Doi Y, Kawano T, Nakagaki O, Takada K, Nii T, Shirai K, Ideishi M, Arakawa K, Mohri M, Takeshita A
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.
J Psychosom Res. 2000 Jul;49(1):77-83. doi: 10.1016/s0022-3999(00)00145-8.
To examine the relation of type A behavior pattern and job strain to angiographically documented coronary stenosis.
Subjects were 197 male Japanese patients with a full-time job. A questionnaire-based interview elicited psychosocial and other factors. Type A behavior pattern was measured by 12 questions, and job strain by the method of Karasek. Significant coronary stenosis was defined when a 75% or greater luminal narrowing occurred at one or more major coronary arteries or when a 50% or greater narrowing occurred at the left main artery. Logistic regression analysis was used to calculate odds ratio (OR) and 95% confidence interval (CI) with adjustment for traditional coronary risk factors and job type.
Type A behavior pattern was related to a statistically non-significant lower prevalence of the coronary stenosis especially in the absence of job strain (adjusted OR 0.6, 95% CI 0.3-1.2). Job strain was non-significantly associated with a modestly increased prevalence of coronary stenosis (OR 1.7, 95% CI 0.6-5.2).
These findings suggest that both the behavioral pattern and psychosocial work environment may be related to coronary artery stenosis.
研究A型行为模式和工作压力与经血管造影证实的冠状动脉狭窄之间的关系。
研究对象为197名有全职工作的日本男性患者。通过基于问卷的访谈获取社会心理因素和其他因素。A型行为模式通过12个问题进行测量，工作压力采用Karasek方法进行测量。当一条或多条主要冠状动脉管腔狭窄达到75%或更高，或左主干动脉狭窄达到50%或更高时，定义为显著冠状动脉狭窄。采用逻辑回归分析计算比值比（OR）和95%置信区间（CI），并对传统冠状动脉危险因素和工作类型进行校正。
A型行为模式与冠状动脉狭窄患病率在统计学上无显著降低相关，尤其是在没有工作压力的情况下（校正OR为0.6，95%CI为0.3-1.2）。工作压力与冠状动脉狭窄患病率适度增加无显著相关性（OR为1.7，95%CI为0.6-5.2）。
这些发现表明，行为模式和社会心理工作环境都可能与冠状动脉狭窄有关。
