Byers R K
Pediatrics. 1975 Nov;56(5):727-35.
Attention is directed to the diagnosis of acute hemorrhagic leukoencephalitis and the possibility of its clinical recognition is discussed. Three case histories, two diagnosed at autopsy and one clinically, are presented. The latter was treated with very generous doses of steroids and recovered spectacularly. On omission of steroids, a mild, temporary clinical recurrence occurred. Clinical, clinico-pathologic, and pathologic aspects of the disease are discussed, and etiologic factors mentioned. Some thoughts on the relationship of this disease to experimental allergic encephalomyelitis are mentioned. Differential diagnosis is considered and the use of biopsy for confirmation of diagnosis especially from herpes encephalitis considered. A plea is made for the trial of treatment with large doses of steroids.
本文关注急性出血性白质脑炎的诊断，并讨论了其临床识别的可能性。文中介绍了三个病例，其中两个经尸检确诊，一个为临床诊断。后者接受了大剂量类固醇治疗，恢复显著。停用类固醇后，出现了轻度、短暂的临床复发。本文讨论了该疾病的临床、临床病理及病理方面，并提及了病因因素。文中还提到了关于该疾病与实验性过敏性脑脊髓炎关系的一些想法。考虑了鉴别诊断，并探讨了通过活检尤其是与疱疹性脑炎鉴别来确诊的应用。呼吁试用大剂量类固醇进行治疗。
