Ball A P, Brookes G R, Farrell I D, Geddes A M, Gould I
Chemotherapy. 1979;25(4):214-21. doi: 10.1159/000237842.
28 patients suffering from a variety of bacterial infections have been treated with cefuroxime. 18 were cured and 6 improved during treatment. Side effects were minimal and intramuscular injection was well tolerated. Serum and urine levels well in excess of the MICs of sensitive organisms were obtained using dosages of 750 mg 8 hourly. Biliary excretion was impaired in the presence of obstruction, but adequate bile levels of cefuroxime were observed following relief of the obstruction. Cefuroxime was widely active against gram-negative bacilli and against Streptococcus faecalis, but less active against Bacteroides spp.
28例患有各种细菌感染的患者接受了头孢呋辛治疗。治疗期间18例治愈，6例病情改善。副作用极小，肌肉注射耐受性良好。每8小时使用750毫克的剂量，血清和尿液水平远超过敏感菌的最低抑菌浓度。存在梗阻时胆汁排泄受损，但梗阻解除后观察到头孢呋辛在胆汁中有足够的水平。头孢呋辛对革兰氏阴性杆菌和粪肠球菌具有广泛活性，但对拟杆菌属活性较低。
