头孢呋辛治疗淋病的临床经验。
Clinical experience in the use of cefuroxime in gonorrhoea.
作者信息
Fowler W, Rahim G, Brown J D
出版信息
Br J Vener Dis. 1978 Dec;54(6):400-2. doi: 10.1136/sti.54.6.400.
Abstract
Cefuroxime, a new antibiotic derived from cephalosporin-C which is very stable in the presence of beta-lactamases produced by Gram-negative organisms, was used to treat 856 male patients and 340 female patients with uncomplicated gonorrhoea. In men the drug was used in three different doses, 1.5 g, 1 g, and 750 mg plus 1 g probenecid; in women 1 g and 750 mg cefuroxime plus 1 g probenecid was used. Cure rates ranged from 94.8% to 99.3%. The antibiotic was well tolerated and was free from side effects. Cefuroxime would be a valuable and efficient substitute for penicillin in the treatment of gonorrhoea due to beta-lactamase-producing strains of gonococci.
摘要
头孢呋辛是一种由头孢菌素 - C衍生而来的新型抗生素，在革兰氏阴性菌产生的β - 内酰胺酶存在的情况下非常稳定，被用于治疗856例男性和340例女性单纯性淋病患者。男性患者使用了三种不同剂量的药物，分别为1.5克、1克以及750毫克加1克丙磺舒；女性患者使用的是1克和750毫克头孢呋辛加1克丙磺舒。治愈率在94.8%至99.3%之间。该抗生素耐受性良好，且无副作用。对于由产生β - 内酰胺酶的淋球菌菌株引起的淋病，头孢呋辛将是治疗中青霉素的一种有价值且有效的替代药物。
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本文引用的文献
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AMPICILLIN BY INJECTION AND BY MOUTH IN THE TREATMENT OF ACUTE GONORRHOEA.注射用及口服氨苄西林治疗急性淋病
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