Shimura M, Yasuda K, Fuse N, Nakazawa M, Tamai M
Department of Ophthalmology, School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Ophthalmologica. 2000;214(6):429-32. doi: 10.1159/000027538.
The purpose of this report is to describe the effective treatment of severe anterior segment inflammation due to Cogan syndrome through the use of topical administration of cyclosporin A. A 47-year-old female patient had been experiencing headaches and difficulties with her vision. Subsequent examination revealed the sudden onset of bilateral conjunctival injection and swelling of bilateral auricles. Despite the multiple treatment (systemic and topical corticosteroid and antibiotic therapy), necrotizing scleritis had appeared bilaterally and the scleral wall was thinning. Topical administration of 1% cyclosporin A was applied to both eyes 4 times a day. After 2 months of this therapy, the epithelial tissue covered the necrotizing tissue and her symptom of ocular pain was relieved and her corrected visual acuity was improved. This is the first case exhibiting that topical cyclosporin A is an effective treatment for severe anterior segment inflammation associated with Cogan syndrome.
本报告的目的是描述通过局部应用环孢素A有效治疗科根综合征引起的严重眼前段炎症。一名47岁女性患者一直患有头痛和视力问题。随后的检查发现双侧结膜充血和双侧耳廓肿胀突然发作。尽管进行了多种治疗（全身和局部使用皮质类固醇和抗生素治疗），双侧仍出现坏死性巩膜炎，巩膜壁变薄。每天4次对双眼局部应用1%环孢素A。经过2个月的这种治疗，上皮组织覆盖了坏死组织，她的眼痛症状得到缓解，矫正视力得到改善。这是首例表明局部应用环孢素A是治疗与科根综合征相关的严重眼前段炎症的有效方法的病例。
