Daun J M, Fenton M J
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA.
J Interferon Cytokine Res. 2000 Oct;20(10):843-55. doi: 10.1089/10799900050163217.
Interleukin-1 (IL-1) is a central mediator of the inflammatory response. It plays a role in both systemic and local immune responses to invading microbes. There are two receptors (IL-1RI and IL-1RII) that mediate the cellular responses. These receptors belong to a family of receptors based on homologous receptor structure within the intracellular signaling domain. Other family members include the Drosophila protein Toll, the recently discovered mammalian Toll-like receptors (TLR), and the IL-18 receptor. Engagement of these receptors by their diverse ligands results in activation of very similar signal transduction cascades through use of common signaling intermediates. These signal transduction cascades lead to the activation of cellular responses that are known to regulate the innate immune response. Therefore, elucidating the function and redundancy of this receptor family is essential to the understanding of the innate immune response. This review examines each member of this receptor family and emphasizes similarities and potential differences in both receptor structure and signal transduction pathways to further the understanding of this complex receptor family.
白细胞介素-1（IL-1）是炎症反应的核心介质。它在对入侵微生物的全身和局部免疫反应中均发挥作用。有两种受体（IL-1RI和IL-1RII）介导细胞反应。这些受体基于细胞内信号域内的同源受体结构属于一个受体家族。其他家族成员包括果蝇蛋白Toll、最近发现的哺乳动物Toll样受体（TLR）以及IL-18受体。这些受体被其不同配体激活后，通过使用共同的信号中间体，导致非常相似的信号转导级联反应的激活。这些信号转导级联反应导致已知调节先天免疫反应的细胞反应的激活。因此，阐明这个受体家族的功能和冗余性对于理解先天免疫反应至关重要。本综述研究了这个受体家族的每个成员，并强调了受体结构和信号转导途径中的相似性和潜在差异，以进一步理解这个复杂的受体家族。
