Subramaniam Sumathi, Stansberg Christine, Cunningham Charles
Sars International Centre for Marine Molecular Biology, High Technology Centre, Thormøhlensgt. 55, N-5008 Bergen, Norway.
Dev Comp Immunol. 2004 May 3;28(5):415-28. doi: 10.1016/j.dci.2003.09.016.
Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region. The nature of this family of proteins and their signal transduction pathway is discussed in this review.
白细胞介素-1是一种关键的炎症细胞因子，它通过I型受体和受体辅助蛋白介导其效应。这两种分子是一个更广泛的蛋白质家族的成员，该家族蛋白质的共同特点是在蛋白质的细胞外区域存在免疫球蛋白结构域，在细胞质区域存在一个TIR结构域。本文综述了该蛋白质家族的性质及其信号转导途径。
