Lin C C, Huang P C
Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung, Taiwan.
Phytother Res. 2000 Nov;14(7):489-94. doi: 10.1002/1099-1573(200011)14:7<489::aid-ptr656>3.0.co;2-g.
Acathopanax senticosus (Rupr. et Maxim.) Harms. is a popular folk medicine used as a nutrient for hepatitis and cancer in Taiwan. In this study, the antioxidant activity of the crude extract and the hepatoprotective activities on CCl(4)- or acetaminophen-induced toxicity in the rat liver were evaluated. Our results suggest that A. senticosus exerts some antioxidant effects. On a CCl(4)- or acetaminophen-intoxicated -model, the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were increased by CCl(4) or acetaminophen administration and reduced by treatment with the plant extract. Histological changes around the hepatic central vein were also recovered by treatments. However, treatments with larger doses of the crude extract of A. senticosus enhanced liver damage. This result suggests that even if A. senticosus had hepatoprotective activity in small doses, treatment with larger doses would possibly induce some cell toxicity.
刺五加（Acathopanax senticosus (Rupr. et Maxim.) Harms.）是台湾一种常用的民间药物，用作肝炎和癌症的营养剂。在本研究中，评估了粗提取物的抗氧化活性以及对大鼠肝脏中四氯化碳或对乙酰氨基酚诱导的毒性的肝保护活性。我们的结果表明，刺五加具有一定的抗氧化作用。在四氯化碳或对乙酰氨基酚中毒模型中，四氯化碳或对乙酰氨基酚给药会使天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平升高，而植物提取物处理可使其降低。肝中央静脉周围的组织学变化也通过处理得到恢复。然而，用较大剂量的刺五加粗提取物处理会加重肝损伤。这一结果表明，即使刺五加小剂量具有肝保护活性，大剂量处理可能会诱导一些细胞毒性。
