Zhang H, Sugiura Y, Goto Y
Department of Anesthesiology and Reanimatology, Fukui Medical University, Matsuoka, Fukui, 910-1193, Japan.
Phytother Res. 2000 Nov;14(7):505-9. doi: 10.1002/1099-1573(200011)14:7<505::aid-ptr648>3.0.co;2-s.
The present study investigated the effects of processed Aconiti tuber (TJ-3022, Tsumura-shuchi-bushi), a traditional herbal medicine (Kampo), on microcirculatory disturbances induced by endotoxin in the rat mesentery. The changes in arteriolar diameter, the velocity of red blood cells in arterioles and the venular microcirculation after endotoxin injection (6 mg/kg, iv) were observed using videomicroscopy. The mean arterial pressure and heart rate were monitored continuously during the experiments. TJ-3022 prevented significantly the decrease of mean arterial pressure, controlled the reduced velocity and apparently also inhibited leukocyte extravasation across venules. However, there were no significant changes in the arteriolar diameter and the heart rate between the groups treated with and without TJ-3022. The results indicate that processed Aconiti tuber (TJ-3022) has protective effects in improving microcirculatory disturbances induced by endotoxin in rat mesentery.
本研究调查了传统草药（汉方）制川乌（TJ - 3022，津村术附汤）对大鼠肠系膜内毒素诱导的微循环障碍的影响。采用视频显微镜观察内毒素注射（6mg/kg，静脉注射）后小动脉直径、小动脉内红细胞速度和微静脉微循环的变化。实验过程中持续监测平均动脉压和心率。TJ - 3022显著预防了平均动脉压的降低，控制了速度的降低，并且明显抑制了白细胞跨微静脉渗出。然而，使用和未使用TJ - 3022治疗的组之间，小动脉直径和心率没有显著变化。结果表明，制川乌（TJ - 3022）对改善大鼠肠系膜内毒素诱导的微循环障碍具有保护作用。
