Capasso A, Saturnino P, Simone F D, Aquino R
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Italy.
Phytother Res. 2000 Nov;14(7):538-40. doi: 10.1002/1099-1573(200011)14:7<538::aid-ptr631>3.0.co;2-1.
The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1-4 (1 x 10(-4) 5 x 10(-5) 1 x 10(-5) M), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion. The results of the present paper suggest that flavonol glycosides from Aristeguietia discolor may play an important role in the control of morphine withdrawal.
研究了变色阿里斯特吉草提取物、部分纯化组分以及四种黄酮醇苷1 - 4对急性吗啡依赖豚鼠离体回肠纳洛酮诱发的戒断收缩的影响。在体外将豚鼠回肠暴露于吗啡4分钟后，加入纳洛酮可观察到强烈收缩。在吗啡给药前10分钟注射的甲醇提取物（50、100和200 mg/mL）、部分纯化组分I、L、M和N（50、100和200 mg/mL）以及黄酮醇苷1 - 4（1×10⁻⁴、5×10⁻⁵、1×10⁻⁵ M），均能以浓度依赖的方式在暴露于吗啡后阻断纳洛酮诱发的收缩。本文结果表明，变色阿里斯特吉草中的黄酮醇苷可能在吗啡戒断控制中发挥重要作用。
