New protopine alkaloids from Aristolochia constricta reduce morphine withdrawal in vitro.

作者信息

Capasso A, De Tommasi N, Rastrelli L, De Simone F

机构信息

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo di Fisciano, Salerno, 84084 Italy.

出版信息

Phytother Res. 2000 Dec;14(8):653-5. doi: 10.1002/1099-1573(200012)14:8<653::aid-ptr695>3.0.co;2-q.

DOI:10.1002/1099-1573(200012)14:8<653::aid-ptr695>3.0.co;2-q

PMID:11114008

Abstract

The present study examines the effect of four new protopine alkaloids (1-4) isolated and purified from the aerial parts of Aristolochia constricta (Aristolichiaceae) on morphine withdrawal in vitro. The results of our experiments indicate that the pure compounds (1-4) significantly and in a concentration-dependent manner reduced the morphine withdrawal. The results of the present study suggest that these new protopine alkaloids may be potential anti-addictive agents.

摘要