Sagel J, Distiller L A, Joffe B I
Postgrad Med J. 1975 Sep;51(599):611-4. doi: 10.1136/pgmj.51.599.611.
The presumptive diagnosis of constitutional delayed adolescence is difficult to substantiate. Clinical examination and routine biochemical testing are not sufficient to exclude isolated gonadotrophin deficiency. Seven males are reported who presented with delayed puberty. These patients were given 100 μg luteinizing hormone-releasing hormone (LH-RH) intravenously, and the luteinizing hormone (LH) and follicle stimulating hormone (FSH) responses were measured. Three of four males who were completely prepubertal (Stage 1) had a normal adult male response. These three patients have progressed further into puberty several months after this diagnostic test. The fourth patient in stage 1 puberty had a prepubertal LH response. A year later the response became adult in type, and 3 months thereafter stage 2 puberty was evident. The LH response to LH-RH thus appears to have some prognostic value in the assessment of males presenting with delayed puberty.
体质性青春期延迟的初步诊断很难得到证实。临床检查和常规生化检测不足以排除孤立性促性腺激素缺乏症。本文报告了7例青春期延迟的男性患者。给这些患者静脉注射100μg促黄体生成素释放激素（LH-RH），并测量促黄体生成素（LH）和促卵泡生成素（FSH）的反应。4例完全处于青春期前（1期）的男性中有3例出现了正常成年男性的反应。在这项诊断测试后的几个月里，这3例患者进一步进入了青春期。第4例处于青春期1期的患者出现青春期前的LH反应。一年后，反应变为成人类型，此后3个月青春期2期明显。因此，LH对LH-RH的反应在评估青春期延迟的男性时似乎具有一定的预后价值。
