下丘脑 - 垂体 - 性腺功能障碍患者的促黄体生成素和促卵泡激素释放激素检测
Luteinizing hormone and follicle stimulating hormone-releasing hormone test in patients with hypothalamic-pituitary-gonadal dysfunction.
作者信息
Mortimer C H, Besser G M, McNeilly A S, Marshall J C, Harsoulis P, Tunbridge W M, Gomez-Pan A, Hall R
出版信息
Br Med J. 1973 Oct 13;4(5884):73-7. doi: 10.1136/bmj.4.5884.73.
Abstract
A standard intravenous 100 mug luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH) test was used to assess the pituitary gonadotrophin responses in 155 patients with a variety of diseases of the hypothalamic-pituitary-gonadal axis. In all but nine patients there was an increase in circulating levels of either LH or FSH in response to the releasing hormone though 137 (88%) were clinically hypogonadal. It was not possible with this test to distinguish between hypothalamic and pituitary causes of hypogonadotrophic hypogonadism, since a variety of LH and FSH responses emerged within the disease groups. However, primary gonadal failure characteristically resulted in exaggerated gonadotrophin response. The potential therapeutic use of the gonadotrophin releasing decapeptide is suggested in certain patients with hypogonadotrophic hypogonadism.
摘要
采用标准静脉注射100微克促黄体生成素/促卵泡激素释放激素（LH/FSH-RH）试验，评估了155例患有下丘脑-垂体-性腺轴各种疾病患者的垂体促性腺激素反应。除9例患者外，其他所有患者对释放激素的反应均表现为LH或FSH循环水平升高，尽管其中137例（88%）临床性腺功能减退。由于疾病组内出现了多种LH和FSH反应，因此该试验无法区分性腺功能减退性性腺功能减退的下丘脑和垂体病因。然而，原发性性腺功能衰竭的特征是促性腺激素反应过度。对于某些性腺功能减退性性腺功能减退患者，提示了促性腺激素释放十肽的潜在治疗用途。
相似文献
1
Luteinizing hormone and follicle stimulating hormone-releasing hormone test in patients with hypothalamic-pituitary-gonadal dysfunction.下丘脑 - 垂体 - 性腺功能障碍患者的促黄体生成素和促卵泡激素释放激素检测
Br Med J. 1973 Oct 13;4(5884):73-7. doi: 10.1136/bmj.4.5884.73.
2
Hypogonadism, galactorrhoea and hyper-prolactinaemia: Evaluation of pituitary gonadotrophins reserve before and under bromocriptine.性腺功能减退、溢乳与高泌乳素血症：溴隐亭治疗前后垂体促性腺激素储备的评估
Acta Endocrinol (Copenh). 1977 Apr;84(4):738-49. doi: 10.1530/acta.0.0840738.
3
[Effect of synthetic LH-RH on the release of LH and FSH in children and adolescents].
Schweiz Med Wochenschr. 1973 Jun 9;103(23):840-2.
4
Isolated pituitary gonadotrophin deficiency: gonadotrophin secretion after synthetic luteinizing hormone and follicle stimulation hormone-releasing hormone.孤立性垂体促性腺激素缺乏症：合成促黄体生成素和促卵泡刺激素释放激素后的促性腺激素分泌
Br Med J. 1972 Dec 16;4(5841):643-5. doi: 10.1136/bmj.4.5841.643.
5
6
Correlation between integrated LH and FSH levels and the response to luteinizing hormone relasing factor (LRF).促黄体生成素（LH）与促卵泡生成素（FSH）综合水平与对促黄体生成素释放因子（LRF）反应之间的相关性。
J Clin Endocrinol Metab. 1976 Dec;43(6):1240-9. doi: 10.1210/jcem-43-6-1240.
7
Changes in plasma inhibin levels following pulsatile gonadotrophin-releasing hormone therapy in a man with idiopathic hypogonadotrophic hypogonadism.特发性低促性腺激素性性腺功能减退男性患者接受脉冲式促性腺激素释放激素治疗后血浆抑制素水平的变化。
Horm Res. 1990;33(1):18-21. doi: 10.1159/000181439.
8
Endocrine investigation and therapy.内分泌检查与治疗。
Urol Clin North Am. 1987 Aug;14(3):471-88.
9
Response to repetitive luteinizing hormone-releasing hormone stimulation in hypothalamic and pituitary disease.
Am J Obstet Gynecol. 1980 Oct 15;138(4):364-8. doi: 10.1016/0002-9378(80)90130-1.
10
[Effect of the steroid sex hormones on the LH and FSH responses to LHRH in the normal subject].[类固醇性激素对正常受试者促黄体生成素（LH）和促卵泡生成素（FSH）对促性腺激素释放激素（LHRH）反应的影响]
Pathol Biol (Paris). 1975 Dec;23(10):917-22.
引用本文的文献
1
Case Report: Hypothalamic Amenorrhea Following COVID-19 Infection and Review of Literatures.病例报告：COVID-19 感染后出现的下丘脑性闭经及文献复习。
Front Endocrinol (Lausanne). 2022 Jun 10;13:840749. doi: 10.3389/fendo.2022.840749. eCollection 2022.
2
The GnRH test in the assessment of patients with pituitary and parapituitary lesions: results of a 5-year retrospective study.促性腺激素释放激素试验在垂体及垂体旁病变患者评估中的应用：一项5年回顾性研究结果
Pituitary. 2008;11(3):271-8. doi: 10.1007/s11102-008-0124-4.
3
Male hypogonadism.男性性腺功能减退
Pituitary. 2008;11(2):171-80. doi: 10.1007/s11102-008-0111-9.
4
Hypogonadotropic hypogonadism in a patient with morbid obesity.一名病态肥胖患者的低促性腺激素性性腺功能减退症。
Obes Surg. 2007 Aug;17(8):1127-31. doi: 10.1007/s11695-007-9190-3.
5
Congenital adrenal hyperplasia in a 66-year-old female.一名66岁女性的先天性肾上腺增生症。
Postgrad Med J. 1981 May;57(667):317-20. doi: 10.1136/pgmj.57.667.317.
6
Pyrexia of unknown origin. Presenting sign of hypothalamic hypopituitarism.不明原因发热。下丘脑垂体功能减退的表现体征。
Postgrad Med J. 1981 May;57(667):310-3. doi: 10.1136/pgmj.57.667.310.
7
The GnRH test in idiopathic hemochromatosis.特发性血色素沉着症中的促性腺激素释放激素试验
J Endocrinol Invest. 1980 Jul-Sep;3(3):223-7. doi: 10.1007/BF03348267.
8
[Stimulation test of the adenohypophysis with arginine, gonadotropin-releasing hormone (GRH), and thyrotropin-releasing hormone (TRH) in 45, XO patients with Turner's syndrome (author's transl)].[对45,XO型特纳综合征患者进行精氨酸、促性腺激素释放激素（GRH）及促甲状腺激素释放激素（TRH）对腺垂体的刺激试验（作者译）]
Arch Gynecol. 1980;229(2):155-60. doi: 10.1007/BF02109953.
9
Hypothalamic regulatory hormones: a review.下丘脑调节激素：综述
J Clin Pathol. 1974 Mar;27(3):173-84. doi: 10.1136/jcp.27.3.173.
10
Diagnostic tests with luteinising hormone releasing hormone should be abandoned.应摒弃使用促黄体生成素释放激素的诊断测试。
Br Med J (Clin Res Ed). 1985 Nov 23;291(6507):1471-2. doi: 10.1136/bmj.291.6507.1471.
本文引用的文献
1
A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.一种用于测定人血浆中游离11-羟基皮质类固醇的简易荧光法。
J Clin Pathol. 1962 Jul;15(4):374-9. doi: 10.1136/jcp.15.4.374.
2
IMMUNOASSAY OF SERUM GROWTH HORMONE IN ACROMEGALIC PATIENTS.肢端肥大症患者血清生长激素的免疫测定
Br Med J. 1964 Nov 14;2(5419):1229-32. doi: 10.1136/bmj.2.5419.1229.
3
Radioimmunoassay of human serum thyrotrophin.人血清促甲状腺素的放射免疫测定
Br Med J. 1971 Mar 13;1(5749):582-5. doi: 10.1136/bmj.1.5749.582.
4
Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones.促性腺激素释放激素：一种调节促黄体生成素和促卵泡激素分泌的多肽。
Science. 1971 Sep 10;173(4001):1036-8. doi: 10.1126/science.173.4001.1036.
5
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence.猪促黄体生成素和促卵泡激素释放激素的结构。I. 推测的氨基酸序列。
Biochem Biophys Res Commun. 1971 Jun 18;43(6):1334-9. doi: 10.1016/s0006-291x(71)80019-0.
6
Isolation and properties of the FSH and LH-releasing hormone.促卵泡激素和促黄体生成素释放激素的分离与特性
Biochem Biophys Res Commun. 1971 Apr 16;43(2):393-9. doi: 10.1016/0006-291x(71)90766-2.
7
Galactorrhoea: successful treatment with reduction of plasma prolactin levels by brom-ergocryptine.溢乳症：用溴隐亭成功治疗，血浆催乳素水平降低。
Br Med J. 1972 Sep 16;3(5828):669-72. doi: 10.1136/bmj.3.5828.669.
8
Isolated pituitary gonadotrophin deficiency: gonadotrophin secretion after synthetic luteinizing hormone and follicle stimulation hormone-releasing hormone.孤立性垂体促性腺激素缺乏症：合成促黄体生成素和促卵泡刺激素释放激素后的促性腺激素分泌
Br Med J. 1972 Dec 16;4(5841):643-5. doi: 10.1136/bmj.4.5841.643.
9
Hormonal responses to synthetic luteinizing hormone and follicle stimulating hormone-releasing hormone in man.人体对合成促黄体生成素和促卵泡激素释放激素的激素反应。
Br Med J. 1972 Jul 29;3(5821):267-71. doi: 10.1136/bmj.3.5821.267.
10
Radioimmunoassay of human prolactin.人催乳素的放射免疫测定
Proc R Soc Med. 1973 Sep;66(9):863-4. doi: 10.1177/003591577306600915.
Zotero 插件