Colitz C M, Malarkey D E, Woychik R P, Wilkinson J E
Department of Companion Animal and Special Species Medicine, North Carolina State University, College of Veterinary Medicine, Raleigh, USA.
Vet Pathol. 2000 Sep;37(5):422-7. doi: 10.1354/vp.37-5-422.
Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous are congenital ocular anomalies that can lead to cataract formation. A line of insertional mutant mice, TgN3261Rpw, generated at the Oak Ridge National Laboratory in a large-scale insertional mutagenesis program was found to have a low incidence (8/243; 3.29%) of multiple developmental ocular abnormalities. The ocular abnormalities include persistent hyperplastic primary vitreous, persistent hyperplastic tunica vasculosa lentis, failure of cleavage of the anterior segment, retrolental fibrovascular membrane, posterior polar cataract, and detached retina. This transgenic mouse line provides an ontogenetic model because of the high degree of similarity of this entity in humans, dogs, and mice.
永存原始玻璃体增生症和永存晶状体血管膜增生症是可导致白内障形成的先天性眼部异常。在橡树岭国家实验室的一个大规模插入诱变计划中产生的一系列插入突变小鼠品系TgN3261Rpw，被发现有多发性发育性眼部异常的低发生率（8/243；3.29%）。眼部异常包括永存原始玻璃体增生症、永存晶状体血管膜增生症、眼前节分裂失败、晶状体后纤维血管膜、后极性白内障和视网膜脱离。由于该实体在人类、狗和小鼠中具有高度相似性，这个转基因小鼠品系提供了一个个体发生模型。
