Jolly M, Sebire N, Harris J, Robinson S, Regan L
Section of Endocrinology and Metabolic Medicine (The Mint Wing), ICSM at St Mary's, Department of Pathology, St Mary's Hospital, Paddington, London, W2 1NY, UK.
Hum Reprod. 2000 Nov;15(11):2433-7. doi: 10.1093/humrep/15.11.2433.
The obstetric risks of adverse outcome during pregnancy in women aged > or =35 years were quantified using a retrospective analysis of data from 385 120 singleton pregnancies in the North West Thames Region, UK, between 1988 and 1997. A comparison of pregnancy outcome was made on the basis of maternal age at delivery: 18-34 years (n = 336 462), 35-40 years (n = 41 327) and women aged > 40 years (n = 7331). Women aged <18 years (n = 5246) were excluded from the study. Data are presented as percentages of 18-34 year old women, 35-40 year old and > 40 year old women, with adjusted odds ratios (OR) according to age group. Pregnant women aged 35-40 years were at increased risk of: gestational diabetes, OR = 2.63 [99% confidence interval (CI) 2.40-2.89]; placenta praevia = 1.93 (1.58-2.35); breech presentation = 1.37 (1.28-1.47); operative vaginal delivery = 1.5 (1.43-1.57); elective Caesarean section = 1.77 (1.68-1.87); emergency Caesarean section = 1.59 (1.52-1.67); postpartum haemorrhage = 1.14 (1.09-1.19); delivery before 32 weeks gestation = 1.41 (1.24-1.61); birthweight below the 5th centile = 1.28 (1.20-1. 36); and stillbirth = 1.41 (1.17-1.70). Women aged >40 years had higher OR for the same risks. Pregnant women aged >/=35 years are at increased risk of complications in pregnancy compared with younger women.
通过对1988年至1997年间英国西北泰晤士地区385120例单胎妊娠数据进行回顾性分析，对年龄大于或等于35岁女性孕期不良结局的产科风险进行了量化。根据分娩时的产妇年龄对妊娠结局进行了比较：18 - 34岁（n = 336462）、35 - 40岁（n = 41327）以及年龄大于40岁的女性（n = 7331）。年龄小于18岁的女性（n = 5246）被排除在研究之外。数据以相对于18 - 34岁女性、35 - 40岁女性以及大于40岁女性的百分比形式呈现，并根据年龄组给出调整后的比值比（OR）。年龄在35 - 40岁的孕妇发生以下情况的风险增加：妊娠期糖尿病，OR = 2.63 [99%置信区间（CI）2.40 - 2.89]；前置胎盘 = 1.93（1.58 - 2.35）；臀位 = 1.37（1.28 - 1.47）；阴道助产 = 1.5（1.43 - 1.57）；择期剖宫产 = 1.77（1.68 - 1.87）；急诊剖宫产 = 1.59（1.52 - 1.67）；产后出血 = 1.14（1.09 - 1.19）；妊娠32周前分娩 = 1.41（1.24 - 1.61）；出生体重低于第5百分位数 = 1.28（1.20 - 1.36）；以及死产 = 1.41（1.17 - 1.70）。年龄大于40岁的女性在相同风险方面的OR更高。与年轻女性相比，年龄大于或等于35岁的孕妇孕期发生并发症的风险增加。
