Department of Obstetrics and Gynecology, University Hospital of Caen, France.
Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):151-6. doi: 10.1016/j.ejogrb.2009.08.006. Epub 2009 Sep 4.
To determine whether young maternal age is associated with increased risks of adverse obstetric, fetal and perinatal outcomes.
Register-based study using the data from a computerized database of a University Hospital for the years 1994-2001. The study population included 8514 primiparous women aged less than 31 who delivered a singleton infant. Using maternal age as a continuous variable, crude and adjusted relative risks (RRs) were estimated for each maternal and perinatal outcome.
Crude and adjusted RRs of anaemia during pregnancy and fetal death consistently increased with younger maternal age. After adjustment for confounding factors, RRs (95% confidence interval) of fetal death and anaemia were respectively 1.37 (1.09-1.70) and 1.27 (1.15-1.40) for a 16-year-old compared to a 20-year-old mother. Younger mothers had significantly decreased risks of obstetric complications (preeclampsia, caesarean section, operative vaginal delivery and post-partum haemorrhage). Higher prevalence of prematurity and low birth weight in infants born to teenagers were not attributable to young maternal age after adjustment for confounding factors.
In our population, younger maternal age was significantly and consistently associated to greater risks of fetal death and anaemia and to lower risks of adverse obstetric outcomes.
确定年轻母亲年龄是否与增加不良产科、胎儿和围产儿结局的风险有关。
使用一所大学医院的计算机数据库中的数据进行基于登记的研究。研究人群包括 1994 年至 2001 年期间年龄小于 31 岁的 8514 名初产妇,分娩单胎婴儿。使用母亲年龄作为连续变量,估计了每种母亲和围产儿结局的粗相对风险(RR)和调整后相对风险(RR)。
妊娠期间贫血和胎儿死亡的粗 RR 和调整 RR 随着母亲年龄的降低而持续增加。在调整混杂因素后,与 20 岁母亲相比,16 岁母亲的胎儿死亡和贫血 RR(95%置信区间)分别为 1.37(1.09-1.70)和 1.27(1.15-1.40)。年轻母亲发生产科并发症(子痫前期、剖宫产、阴道分娩和产后出血)的风险显著降低。在调整混杂因素后,青少年母亲所生婴儿的早产和低出生体重的更高发生率与母亲年龄无关。
在我们的人群中,年轻母亲年龄与胎儿死亡和贫血的风险增加显著相关,与不良产科结局的风险降低显著相关。