Jolly M C, Sebire N, Harris J, Robinson S, Regan L
Imperial College of Science Technology and Medicine, St. Mary's Campus, London, United Kingdom.
Obstet Gynecol. 2000 Dec;96(6):962-6. doi: 10.1016/s0029-7844(00)01075-9.
To quantify the age-related risks of adverse outcome during pregnancy in women less than 18 years old.
We analyzed data from 341,708 completed singleton pregnancies in the North West Thames region between 1988 and 1997. Pregnancy outcomes were compared by age at delivery in women less than 18 years old (n = 5246) and 18-34 years old (n = 336,462); women 35 years old or older (n = 48,658) were excluded. Data are presented as percentages of women less than 18 and 18-34-year-old women, with adjusted odds ratios (OR) and 99% confidence intervals (CI).
Pregnancy in women less than 18 years old was associated with increased risk of preterm labor before 32 weeks' gestation (OR 1.41, CI 1.02, 1.90), maternal anemia (OR 1.82, CI 1.63, 2.03), chest infection (OR 2.70, CI 1.21, 6.70), and urinary tract infection (OR 1.60, CI 1.11, 2.31), but less obstetric intervention. Operative vaginal delivery (OR 0. 46, CI 0.41, 0.56), elective cesarean (OR 0.47, CI 0.35, 0.65), or emergency cesarean (OR 0.45, CI 0.38, 0.53) were all less likely in women aged less than 18 years. Women less than 18 years old were no more likely to have stillbirths (OR 0.75, CI 0.42, 1.34) or small-for-gestational-age infants (OR 0.95, CI 0.82, 1.09) than women aged 18-34 years.
Pregnant women less than 18 years old were more likely to deliver preterm than older women. In most other respects they have less maternal and perinatal morbidity and were more likely to have normal vaginal deliveries.
量化18岁以下女性孕期不良结局的年龄相关风险。
我们分析了1988年至1997年间泰晤士河西北地区341,708例单胎妊娠完整数据。比较了18岁以下（n = 5246）和18 - 34岁（n = 336,462）女性的分娩年龄与妊娠结局；排除了35岁及以上（n = 48,658）的女性。数据以18岁以下女性和18 - 34岁女性的百分比形式呈现，并给出调整后的优势比（OR）和99%置信区间（CI）。
18岁以下女性怀孕与妊娠32周前早产风险增加（OR 1.41，CI 1.02，1.90）、母体贫血（OR 1.82，CI 1.63，2.03）、胸部感染（OR 2.70，CI 1.21，6.70）及尿路感染（OR 1.60，CI 1.11，2.31）相关，但产科干预较少。18岁以下女性进行阴道助产（OR 0.46，CI 0.41，0.56）、择期剖宫产（OR 0.47，CI 0.35，0.65）或急诊剖宫产（OR 0.45，CI 0.38，0.53）的可能性均较低。与18 - 34岁女性相比，18岁以下女性死产（OR 0.75，CI 0.42，1.34）或小于胎龄儿（OR 0.95，CI 0.82，1.09）的可能性并无增加。
18岁以下孕妇比年长孕妇更易早产。在大多数其他方面，她们的母体和围产期发病率较低，且更有可能顺产。
