Fyrö B, Petterson U, Sedvall G
Psychopharmacologia. 1975 Oct 14;44(1):99-103. doi: 10.1007/BF00421192.
Clinical effects, levels of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF) and lithium levels in serum were examined in 13 manic depressive patients acutely admitted because of a manic or hypomanic episode. Patients were examined before and 12 days after the beginning of lithium treatment. Manic scores were significantly reduced during treatment. The levels of 5-HIAA as well as HVA increased significantly during treatment. The HVA to 5-HIAA ratio was significantly reduced, indicating a more pronounced change in 5-HIAA than in HVA. The 5-HIAA and HVA levels before as well as after 12 days of treatment were significantly correlated. No significant correlation was found between manic scores and monoamine metabolites in CSF or between lithium level in serum and reduction of manic scores or elevation of monoamine metabolites in CSF in the relative small number of patients studied.
对13例因躁狂或轻躁狂发作而急性入院的双相情感障碍患者，检测其临床疗效、脑脊液（CSF）中5-羟吲哚乙酸（5-HIAA）和高香草酸（HVA）水平以及血清锂水平。在锂治疗开始前和开始后12天对患者进行检查。治疗期间躁狂评分显著降低。治疗期间5-HIAA以及HVA水平显著升高。HVA与5-HIAA的比值显著降低，表明5-HIAA的变化比HVA更明显。治疗前和治疗12天后的5-HIAA和HVA水平显著相关。在所研究的相对少数患者中，未发现CSF中躁狂评分与单胺代谢产物之间、血清锂水平与躁狂评分降低或CSF中单胺代谢产物升高之间存在显著相关性。
