Berrettini W H, Nurnberger J I, Scheinin M, Seppala T, Linnoila M, Narrow W, Simmons-Alling S, Gershon E S
Biol Psychiatry. 1985 Mar;20(3):257-69. doi: 10.1016/0006-3223(85)90055-1.
In a search for trait markers in manic-depressive illness, we studied cerebrospinal fluid (CSF) and plasma monoamines and their metabolites in 25 lithium-treated euthymic bipolar patients (12 of whom provided unmedicated samples) and 30 normal volunteers. No group differences were found. Lithium treatment showed a trend to increase CSF hydroxy-indoleacetic acid (HIAA) (p = 0.05). Dopaminergic and serotonergic metabolites were highly correlated in the CSF of all three groups. We found no evidence of a trait marker for manic-depressive illness among CSF monoamines and their metabolites.
为寻找躁郁症的特质标志物，我们研究了25名接受锂盐治疗且病情处于缓解期的双相情感障碍患者（其中12人提供了未服药时的样本）以及30名正常志愿者的脑脊液（CSF）和血浆单胺及其代谢产物。未发现组间差异。锂盐治疗显示出脑脊液中羟吲哚乙酸（HIAA）有升高趋势（p = 0.05）。所有三组的脑脊液中多巴胺能和5-羟色胺能代谢产物高度相关。我们未发现脑脊液单胺及其代谢产物中有躁郁症特质标志物的证据。
