Träskman-Bendz L, Asberg M, Bertilsson L, Thorén P
Acta Psychiatr Scand. 1984 Apr;69(4):333-42. doi: 10.1111/j.1600-0447.1984.tb02503.x.
Repeated lumbar punctures in 16 healthy volunteers showed reproducible concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF). In seven depressed patients, studied during two or three illness periods, the metabolite concentrations were also fairly stable. In 11 patients CSF concentrations of 5-HIAA, but not of HVA, were higher after recovery than during depression. This increase of 5-HIAA after recovery was confined to patients whose initial serotonin metabolite levels were low. The finding constitutes further evidence of a biochemical heterogeneity within the depressive disorders, and suggests that patients whose CSF 5-HIAA is low during a depressive episode may have a less stable serotonin system than other patients with depressive illness.
对16名健康志愿者进行多次腰椎穿刺后发现，脑脊液（CSF）中5-羟吲哚乙酸（5-HIAA）和高香草酸（HVA）的浓度具有可重复性。在7名抑郁症患者的两到三个患病阶段进行研究时，代谢物浓度也相当稳定。11名患者康复后脑脊液中5-HIAA的浓度升高，但HVA未升高。康复后5-HIAA的这种升高仅限于初始血清素代谢物水平较低的患者。这一发现进一步证明了抑郁症存在生化异质性，并表明在抑郁发作期间脑脊液5-HIAA水平较低的患者，其血清素系统可能不如其他抑郁症患者稳定。
