Jost M, Kari C, Rodeck U
Department of Dermatology and Cutaneous Biology, Institute for Molecular Medicine and the Kimmel Cancer Center, Thomas Jefferson University, 319 BLSB233 S. 10th St., Philadelphia, PA 19107, USA.
Eur J Dermatol. 2000 Oct-Nov;10(7):505-10.
Epidermal keratinocytes express both the epidermal growth factor receptor (EGFR) and several of its ligands, establishing the constitutive elements of an autocrine loop in this cell type. Activation of the EGFR provides signals essential to several aspects of normal keratinocyte biology including cell cycle progression, differentiation, cell movement and cellular survival. It may be argued that enhanced keratinocyte survival via EGFR activation is the most important function as it limits the manifestation of other phenotypes. The frequent deregulation of EGFR expression and activation in benign and malignant hyperproliferative skin diseases motivates the investigation of EGFR-dependent intracellular pathways which contribute to the varied EGFR-dependent phenotypes.
表皮角质形成细胞表达表皮生长因子受体（EGFR）及其多种配体，从而在这种细胞类型中建立了自分泌环的组成要素。EGFR的激活为正常角质形成细胞生物学的多个方面提供了至关重要的信号，包括细胞周期进程、分化、细胞运动和细胞存活。可以认为，通过EGFR激活增强角质形成细胞存活是最重要的功能，因为它限制了其他表型的表现。在良性和恶性增生性皮肤病中，EGFR表达和激活经常失调，这促使人们对EGFR依赖的细胞内途径进行研究，这些途径导致了多种EGFR依赖的表型。
