Abramson Cancer Center, CAMB Graduate Group, Department of Dermatology, Cutaneous Phenomics and Transcriptomics Core, Penn SBDRC, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.
Int J Mol Sci. 2022 Mar 23;23(7):3478. doi: 10.3390/ijms23073478.
Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.
非黑色素瘤皮肤癌是皮肤恶性肿瘤，是美国最常见的癌症类型。它主要由基底细胞癌和鳞状细胞癌（cSCC）组成。cSCC 的发病率正在上升，导致发病率和治疗费用不断增加；目前每年超过 10 亿美元。在这里，我们回顾了定义 cSCC 的分子基础和发展的研究，旨在为发病机制提供新的见解，并推动新型、降低成本和发病率的治疗方法的发展。
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