Hida Wilson Takashi, Nogueira Daniel Cruz, Schaefer Arthur, Dantas Paulo Elias Correa, Dantas Maria Cristina Nishiwaki
Departamento de Oftalmologia, Faculdade de Ciências Médicas, Santa Casa de Misericórdia de São Paulo, Rua Afonso de Freitas 488, São Paulo, SP, CEP 04006-052 Brazil.
Arq Bras Oftalmol. 2006 Nov-Dec;69(6):851-6. doi: 10.1590/s0004-27492006000600013.
To compare the topical use of 0.025% ketotifen fumarate and 0.1% olopatadine hydrochloride in the treatment of patients with vernal keratoconjunctivitis.
A study performed in one center, simple masked, parallel-group compared ketotifen and olopatadine. These patients were evaluated on four visits during the treatment (days 1, 7, 14 and 21), defined by ratings scores. Adverse events were the main variable of safety rating.
On evaluating ocular itching, burning, tearing, conjunctival hyperemia, mucous discharge and photophobia, the ketotifen group showed a significant improvement of total signs and symptoms (p<0.05). Between the baseline and the 2nd visit, treatment with olopatadine resulted in decreased burning, but after the 4th visit, ketotifen was slightly better. Sand sensation, papillae and Horner-Trantas dots were not significantly different in both groups.
Both drugs were efficient and safe relieving the main symptoms and signs of vernal keratoconjunctivitis. Between the same timepoints, there was a significant difference in favor of ketotifen-treated patients (p<0.05), showing improvement of itching, tearing, conjunctival hyperemia, mucous discharge and photophobia.
比较0.025%富马酸酮替芬和0.1%盐酸奥洛他定局部用药治疗春季角结膜炎患者的效果。
在一个中心进行的一项研究，采用简单盲法、平行组比较酮替芬和奥洛他定。这些患者在治疗期间（第1、7、14和21天）进行了4次访视，通过评分进行评估。不良事件是安全性评级的主要变量。
在评估眼部瘙痒、烧灼感、流泪、结膜充血、黏液分泌物和畏光情况时，酮替芬组的总体体征和症状有显著改善（p<0.05）。在基线和第2次访视之间，奥洛他定治疗使烧灼感减轻，但在第4次访视后，酮替芬稍好。两组的沙粒感、乳头和赫纳-特兰塔小点无显著差异。
两种药物在缓解春季角结膜炎的主要症状和体征方面均有效且安全。在相同时间点之间，酮替芬治疗的患者有显著差异（p<0.05），表现为瘙痒、流泪、结膜充血、黏液分泌物和畏光症状改善。
