Trenholme C M, Williams R L, Desjardins R E, Frischer H, Carson P E, Rieckmann K H, Canfield C J
Science. 1975 Nov 21;190(4216):792-4. doi: 10.1126/science.1105787.
Mefloquine hydrochloride, a new 4-quinolinemethanol, was administered as a single oral dose to 47 volunteers infected with malaria. Treatment resulted in rapid clearence of fever and parasitemia. No recrudescence of parasites was observed after treatment of chloroquine-sensitive infections of Plasmodium falciparum. More significantly, in nonimmune persons with chloroquine-resistant infections, 1 gram of mefloquine cured 10 of 12 patients and 1.5 grams cured all 8 patients who received this dose of the drug. The marked activity of a single dose of mefloquine against chloroquine-resistant strains of Plasmodium falciparum suggests that this agent may be more useful than currently available drugs are for the treatment of drug-resistant malaria.
盐酸甲氟喹，一种新型4-喹啉甲醇，以单次口服剂量给予47名感染疟疾的志愿者。治疗导致发热和寄生虫血症迅速清除。在治疗恶性疟原虫氯喹敏感感染后未观察到寄生虫复发。更显著的是，在患有氯喹耐药感染的非免疫人群中，1克甲氟喹治愈了12名患者中的10名，1.5克治愈了接受该剂量药物的所有8名患者。单剂量甲氟喹对恶性疟原虫氯喹耐药菌株具有显著活性，这表明该药物可能比目前可用的药物更有效地治疗耐药性疟疾。
