盐酸甲氟喹（WR 142490）对耐药疟疾的预防作用。
Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug-resistant malaria.
作者信息
Rieckmann K H, Trenholme G M, Williams R L, Carson P E, Frischer H, Desjardins R E
出版信息
Bull World Health Organ. 1974;51(4):375-7.
Abstract
In preliminary studies with mefloquine (WR 142 490) a single dose exerted prolonged suppressive activity against a drug-resistant strain of Plasmodium falciparum. Development of patent parasitaemia was prevented when nonimmune persons were exposed to infected mosquitos 2 weeks after medication, and it was delayed when exposure occurred 3 weeks after drug administration.
摘要
在对甲氟喹（WR 142 490）的初步研究中，单次给药对恶性疟原虫的耐药菌株具有延长的抑制活性。当非免疫个体在用药后2周接触感染的蚊子时，可预防显性寄生虫血症的出现；当在给药后3周接触蚊子时，显性寄生虫血症的出现则会延迟。
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