Schneck M E, Fortune B, Adams A J
Visual Sciences Program, School of Optometry, University of California, 94720-2020, Berkeley, CA, USA.
Vision Res. 2000;40(24):3447-53. doi: 10.1016/s0042-6989(00)00173-5.
The effect of acute blood glucose elevations on human outer retinal function was examined. Electrooculograms were recorded as the background light cycled on/off with a 2-min period, eliciting rapid changes in the corneo-retinal standing potential known as the fast-oscillation of the electrooculogram. Recordings were made while subjects fasted and after they consumed 100 g of D-glucose. In all subjects, blood glucose levels strongly affected fast oscillation amplitude, which reflects photoreceptor-driven changes in RPE cell chloride concentration. The sensitivity of RPE metabolism to glucose fluctuations may relate to changes in the blood-retinal barrier that are known to occur in diabetes (e.g. macular edema).
