感染在长期插管新生儿获得性声门下狭窄发生中的作用。
Role of infection in the development of acquired subglottic stenosis in neonates with prolonged intubation.
作者信息
Suzumura H, Nitta A, Tanaka G, Kuwashima S, Hirabayashi H
机构信息
Department of Pediatrics, Dokkyo University School of Medicine, Shimotsuga-gun, Tochigi, Japan.
出版信息
Pediatr Int. 2000 Oct;42(5):508-13. doi: 10.1046/j.1442-200x.2000.01273.x.
OBJECTIVE
To examine whether clinically diagnosed infection correlates with subsequent development of subglottic stenosis in intubated neonates.
METHODS
Sixty-two neonatal infants intubated for more than 14 days were examined. Several risk factors for subglottic stenosis, including infection, duration of intubation, frequency of intubation, the size of the endotracheal tube etc., were evaluated by multiple logistic regression analysis.
RESULTS
Infection that occurred within 14 days of intubation showed a positive correlation with subsequent subglottic stenosis. The duration of intubation, frequency of intubation and the size of the endotracheal tube did not affect the development of subglottic stenosis. The majority of infections were considered to be respiratory tract infections, including pneumonia.
CONCLUSIONS
Infection occurring within 14 days of intubation is considered to be a risk factor for acquired subglottic stenosis in neonates intubated for more than 14 days. Prevention of infection within 14 days of intubation may reduce the incidence of subglottic stenosis in neonates.
目的
探讨临床诊断的感染与插管新生儿声门下狭窄的后续发生是否相关。
方法
对62例插管时间超过14天的新生儿进行检查。通过多因素logistic回归分析评估声门下狭窄的多个危险因素，包括感染、插管持续时间、插管频率、气管内导管尺寸等。
结果
插管后14天内发生的感染与随后的声门下狭窄呈正相关。插管持续时间、插管频率和气管内导管尺寸并未影响声门下狭窄的发生。大多数感染被认为是呼吸道感染，包括肺炎。
结论
插管后14天内发生的感染被认为是插管超过14天的新生儿获得性声门下狭窄的危险因素。预防插管后14天内的感染可能会降低新生儿声门下狭窄的发生率。
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