Arroyo V, Bosch J, Mauri M, Viver J, Mas A, Rivera F, Rodes J
Eur J Clin Invest. 1979 Feb;9(1):69-73. doi: 10.1111/j.1365-2362.1979.tb01669.x.
The interrelationships between the renin-angiotensin-aldosterone system, renal haemodynamics and urinary sodium excretion were investigated in fifty-six non-azotaemic cirrhotics with ascites. In twelve additional patients the renal renin secretion rate was also studied. Plasma renin activity and concentration and plasma aldosterone ranged from normal to very high values. There was a significant inverse relationship between plasma aldosterone and the urinary sodium excretion. Plasma aldosterone showed a highly significant direct correlation with plasma renin activity, and plasma renin concentration was closely and directly related to the estimated renin secretion rate. Neither plasma renin activity, plasma renin concnetration nor the estimated renin secretion rate correlated with the renal plasma flow or the glomerular filtration rate. These results suggest that in non-azotaemic cirrhosis with ascites the renin-angiotensin-aldosterone system is an important factor influencing sodium excretion, increased plasma renin and aldosterone concentrations are mainly due to an increased secretion rate, and total renal perfusion is not a major factor influencing renin secretion.
对56例无氮质血症的肝硬化腹水患者的肾素-血管紧张素-醛固酮系统、肾血流动力学和尿钠排泄之间的相互关系进行了研究。另外对12例患者也研究了肾素分泌率。血浆肾素活性、浓度及血浆醛固酮水平从正常到极高值不等。血浆醛固酮与尿钠排泄之间存在显著的负相关。血浆醛固酮与血浆肾素活性呈高度显著的正相关，血浆肾素浓度与估计的肾素分泌率密切正相关。血浆肾素活性、血浆肾素浓度及估计的肾素分泌率均与肾血浆流量或肾小球滤过率无相关性。这些结果提示，在无氮质血症的肝硬化腹水中，肾素-血管紧张素-醛固酮系统是影响钠排泄的重要因素，血浆肾素和醛固酮浓度升高主要是由于分泌率增加，而肾总灌注不是影响肾素分泌的主要因素。
