Chevret E, Volpi E V, Sheer D
Human Cytogenetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom.
Cytogenet Cell Genet. 2000;90(1-2):13-21. doi: 10.1159/000015654.
A key feature of interphase chromosomes is their compaction into discrete "territories" in the nucleus. In this review, we focus on the compartmentalization of the genome conferred by this organization and evaluate our current understanding of the role of large-scale chromatin folding in the regulation of gene expression. We examine evidence for the hypothesis that transcription occurs at the external surfaces of chromosomes and follow its evolution to include transcription at the surfaces of chromatin-rich domains within chromosomes. We also present prevailing views regarding the details of large-scale chromatin folding and the functional relationship between chromatin and the enigmatic nuclear matrix.
间期染色体的一个关键特征是它们在细胞核中压缩成离散的“区域”。在本综述中，我们聚焦于这种组织方式赋予基因组的分区，并评估我们目前对大规模染色质折叠在基因表达调控中作用的理解。我们审视了转录发生在染色体外表面这一假说的证据，并追踪其演变，以纳入转录发生在染色体内富含染色质区域表面的观点。我们还介绍了关于大规模染色质折叠细节以及染色质与神秘核基质之间功能关系的主流观点。
