Illés J
Zentralbl Bakteriol Orig A. 1975 Aug;232(4):477-81.
The issue of immunity in the case of enteric infections caused by bacteria is still widely unresolved. To clarify this, weaned piglets 6-7 weeks of age were used as a model, because of the particular susceptibility to colienterotoxemia shown by them at this particular age. The experimental design was as follows. The animals were immunized orally and parenterally (i.v. and i.p. routes) by means of a vaccine consisting of bacteria incapable of reproduction. 14 days later, the animals were challenged orally with virulent EC-O 141 B 85 and EC-O 139 B 82. The results have shown that a) parenteral immunization did not induce protection against oral infection with virulent E. coli; b) repeated oral immunization produced measurable immunity against oral infection; and c) 1 7-hour broth culture proved to be particularly suitable for oral infection. Results also point to the fact local immunity in the intestine as present after enteric infection by bacteria may be artificially induced only by protective oral immunization.
由细菌引起的肠道感染情况下的免疫问题仍未得到广泛解决。为了阐明这一点，6至7周龄的断奶仔猪被用作模型，因为它们在这个特定年龄对大肠杆菌肠毒素血症表现出特别的易感性。实验设计如下。通过由不能繁殖的细菌组成的疫苗对动物进行口服和非肠道（静脉内和腹腔内途径）免疫。14天后，给动物口服强毒EC-O 141 B 85和EC-O 139 B 82进行攻毒。结果表明：a）非肠道免疫不能诱导对口服强毒大肠杆菌感染的保护作用；b）重复口服免疫产生了针对口服感染的可测量的免疫力；c）17小时的肉汤培养物被证明特别适合口服感染。结果还表明，肠道细菌感染后存在的肠道局部免疫可能仅通过保护性口服免疫人工诱导产生。
